A clinical observation is presented of a young patient with a rare form of homozygous mutation, which caused recurrent pulmonary embolism, ischemic stroke in the left middle cerebral artery basin. To determine the etiology of recurrent thrombosis, instrumental diagnostic methods were performed to exclude dissection of extra- and intracranial arteries, heart diseases, as well as laboratory methods to detect thrombophilia, antiphospholipid syndrome, connective tissue diseases, and the blood system. According to the results of the examination, the patient revealed a homozygous mutation of the plasminogen activator inhibitor PAI-1, which, in the absence of other factors, can be considered as a probable cause of recurrent thrombosis. During treatment, the patients condition improved, focal neurological symptoms partially regressed. As a secondary prophylaxis, the patient was prescribed lifelong administration of warfarin under the control of INR.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.