Eosinophilic leucocytes only rarely take up bacteria. Mesnil (Annales de l'lnstitut Pasteur, May, 1895) has noted, in the frog, eosinophilic cells in the act of engulfing anthrax bacilli. We have still more recently noted the taking up of the diphtheria bacillus by the eosinophiles of a guinea-pig immunized by a strong dose of anti-diphtheria serum.f Samoiloff, Arbeiten des pharmakologischen Institutes zu Dorpat, IX, 1893. J Lipski, Ibid. * Werigo, Les globules blancs protecteurs du sang: Annales de ITnstitut Pasteur, 1892. f J. Massart et Ch. Bordet, Journal de la Societe royale des sciences naturelles et medicales de Bruxelles, 1890. of them have taken up organisms. The number of these leucocytes * See Cantacuzene, Recherches sur le mode de destruction du vibrion chol£rique dans l'organisme, 1894. t Pfeiffer, Zeitschrift fur Hygiene, 1894, XVIII, p. 1. STUDIES ON THE SERUM OF VACCINATED ANIMALS. 35 with the spirillum of recurrent fev^r.* Mesnil noted a similar fact with the Bacillus anthracis.f V. cholerce (culture from Constantinople). -Same result. B. typhosus. -There are many organisms within leucocytes of which the majority have been transformed into rounded or oval granules which stain shades varying from blue to pink. The change is similar to that noted in the cholera vibrio. There are a few intact bacteria within cells that stain with eosin. The bacilli that have not been taken up by phagocytes have a normal appearance. B. coli. -The results are similar to those with B. typhosus.The same intracellular granulation is to be noted due to the contraction of the organism. There are also some bacteria within the cells that appear swollen. Stains are all the way from blue to red.No change in the organism outside the cells.Bacillus of Hog Cholera. -The results are also similar to those noted under cholera and typhoid. Within the phagocytes, in addition to normal bacteria, granules stained either with blue or with eosin are noted. The organisms outside leucocytes are intact.Bacillus of Danysz. -This organism was discovered by Danysz in an epidemic among rats, and when injected into these animals causes a contagious and fatal enteritis. The organism is nonpathogenic for rabbits and birds, and kills only rats, mice, and fieldmice, so that it is actually being used in agricultural circles for the purpose of destroying these harmful animals. It is a cocco-bacillus that does not stain by Gram and resembles the colon bacillus in general.When subjected to the leucocytes of the guinea-pig it is taken up with extraordinary avidity. The phagocytes take up so many bacteria that each one appears to be stuffed with them.The organisms that have been taken up, when examined after the usual period, are found colored violet and at times .red. Bacillus diphtheria;. -There is a very marked phagocytosis.The shape of the organisms is not changed (at least in 4 hours), but the reaction to dyes is extraordinarily modified. The majority of diphtheria bacilli taken up by phagocytes are colored a deep red or violet.Outside the leucocytes,...
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