Cervical cancer is the top rank of the common malignant tumors among women in Taiwan. In all of the universal diagnosis, Pap smear is the most convenient but has higher false negative. Although Colposcopy has higher accuracy, it can 1 detect lesions at the endocervix tissue. Autofluorescence diagnosis is characterized by the stimulation of endogenous fluorophores, such as. collage, NADH, and FAD in normal and abnormal tissue. It is minimum invasion and real time. I n this research, we developed a small autofluorescence spectra measurement system. It consists of o sensitive PMT with a double gratings spectrometer; a Y typefiber including /&excitation to IPemissionfibers. and xenon lamp with monochromate as multi-wavelength light source. We utilized this autofluorescence spectra and excitation-emission matrices (EEM) in cervical cancer study and measured normal and abnormal tissues (cervical intraepithelial neoplasia, ClN squamous cell carcinoma:SCC). EEM represented multi-excited wavelength induced dfferenf range wavelength af the emission. It let us get more information about tissues 'characteristic. We usedpartial least squares (PLS) to analyze these data of the spectra and EEM, The result shows diagnostic abilify by autofluorescence fechnology can apply to ClN and using PLS analyzedpathological changes of the cervical tissue has discriminative. We also got high
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