Novel 4-{3-[2-(2-morpholin-4-yl-ethoxy)phenyl]-5-phenyl-pyrazol-
1-yl}benzenesulfonamide (7) was synthesized and evaluated for its
anti-breast cancer activity. It was prepared by cyclocondensation reaction
of morpholine-substituted β-diketone, 1-[2-(2-morpholin-4-yl-ethoxy)-
phenyl]-3-phenyl-propane-1,3-dione (3) with 4-hydrazinobenzenesulfonamide
hydrochloride (6). Chemical structure of titled compound
(7) was confirmed by FTIR, 1H & 13C NMR and HRMS spectroscoic
analyses. The anticancer activity of titled compound 7 was evaluated
against MCF-7 breast cancer cell line by MTT assay. Molecular docking
was performed to predict its plausible binding with the estrogen
receptor α(ERα) using Molecular Operating Environment 2019.0101
software. The MTT assay results showed that titled compound 7 exhibited
better anticancer activity against MCF7 cells (IC50: 4.25 μM) than
standard drug, 4-hydroxytamoxifen (IC50: 8.22 μM). Results of molecular
docking studies were found in good agreement with the results
of anticancer evaluation, as the binding score of titled compound 7
(-16.9872 kcal/mol) was lower as compared to 4-hydroxytamoxifen
(-15.1112 kcal/mol). The new cationic interaction of titled compound 7
with Trp383 and hydrogen bonding interaction with Phe404 in active
site of ERα made its anticancer activity better than 4-hydroxytamoxifen.
Thus, 4-{3-[2-(2-morpholin-4-yl-ethoxy)phenyl]-5-phenyl-pyrazol-
1-yl}benzenesulfonamide (7) was emerged as a potent anti-breast
cancer agent.
In the present work, two different methods (sol-gel and biological) were adopted for synthesis of ZnO nanoparticles. The synthesized
nanoparticles were characterized for its optical, structural, photocatalytic, biological activities. Both synthesized nanoparticles demonstrated
a wurtzite hexagonal structure. The morphological analysis revealed that most of the particles spherical shape. The photocatalytic activity
of the synthesized nanoparticles was determined through the degradation of acid black 1 dye in which the biosynthesized ZnO NPs provided
good performance as compared to that the chemically synthesized ZnO NPs. Furthermore, antibacterial activity, the zone of inhibition of
bacterial growth was higher in the biosynthesized ZnO NPs and also antioxidant activity.
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