While graphene and its derivatives have been suggested as a potential nanomedicine in several biomimetic models, their specific roles in immunological disorders still remain elusive. Graphene quantum dots (GQDs) may be suitable for treating intestinal bowel diseases (IBDs) because of their low toxicity in vivo and ease of clearance. Here, GQDs are intraperitoneally injected to dextran sulfate sodium (DSS)–induced chronic and acute colitis model, and its efficacy has been confirmed. In particular, GQDs effectively prevent tissue degeneration and ameliorate intestinal inflammation by inhibiting TH1/TH17 polarization. Moreover, GQDs switch the polarization of macrophages from classically activated M1 to M2 and enhance intestinal infiltration of regulatory T cells (Tregs). Therefore, GQDs effectively attenuate excessive inflammation by regulating immune cells, indicating that they can be used as promising alternative therapeutic agents for the treatment of autoimmune disorders, including IBDs.
Hemodialysis (HD) patients had a high rate of infection transmission and mortality during the middle east respiratory syndrome coronavirus (MERS-CoV) outbreak in Saudi Arabia. A standardized guideline on isolation technique for exposed HD patients is not available. Thus, this study aimed to evaluate the effect of different isolation strategies on the prevention of secondary viral transmission and clinical outcomes among exposed HD patients. During the 2015 MERS-CoV outbreak in Korea, 116 patients in 3 HD units were incidentally exposed to individuals with confirmed MERS-CoV infection and underwent different types of isolation, which were as follows: single-room isolation (n = 54, 47%), cohort isolation (n = 46, 40%), and self-imposed quarantine (n = 16, 13%). The primary outcome was rate of secondary viral transmission. The secondary outcome measures were changes in clinical and biochemical markers during the isolation period, difference in clinical and biochemical markers according to the types of isolation practice, and effect of isolation practice on patient survival. During a mean isolation period of 15 days, no further cases of secondary transmission were detected among HD patients. Plasma hemoglobin, serum calcium, and serum albumin levels and single-pool Kt/V decreased during the isolation period but normalized thereafter. Patients who were subjected to self-imposed quarantine had higher systolic and diastolic blood pressure, lower total cholesterol level, and lower Kt/V than those who underwent single-room or cohort isolation. During the 24-month follow-up period, 12 patients died. However, none of the deaths occurred during the isolation period, and no differences were observed in patient survival rate according to different isolation strategies. Although 116 participants in 3 HD units were incidentally exposed to MERS-CoV during the 2015 outbreak in Korea, strict patient surveillance and proper isolation practice prevented secondary transmission of the virus. Thus, a renal disaster protocol, which includes proper contact surveillance and isolation practice, must be established in the future to accommodate the needs of HD patients during disasters or outbreaks.
While the neuropathological characteristics of Niemann-Pick disease type C (NPC) result in a fatal diagnosis, the development of clinically available therapeutic agent remains a challenge. Here we propose graphene quantum dots (GQDs) as a potential candidate for the impaired functions in NPC in vivo. In addition to the previous findings that GQDs exhibit negligible longterm toxicity and are capable of penetrating the blood−brain barrier, GQD treatment reduces the aggregation of cholesterol in the lysosome through expressed physical interactions. GQDs also promote autophagy and restore defective autophagic flux, which, in turn, decreases the atypical accumulation of autophagic vacuoles. More importantly, the injection of GQDs inhibits the loss of Purkinje cells in the cerebellum while also demonstrating reduced activation of microglia. The ability of GQDs to alleviate impaired functions in NPC proves the promise and potential of the use of GQDs toward resolving NPC and other related disorders.
Intel SGX aims to provide the confidentiality of user data on untrusted cloud machines. However, applications that process confidential user data may contain bugs that leak information or be programmed maliciously to collect user data. Existing research that attempts to solve this problem does not consider multi-client isolation in a single enclave. We show that by not supporting such in-enclave isolation, they incur considerable slowdown when concurrently processing multiple clients in different enclave processes, due to the limitations of SGX. This paper proposes CHANCEL, a sandbox designed for multi-client isolation within a single SGX enclave. In particular, CHANCEL allows a program's threads to access both a per-thread memory region and a shared read-only memory region while servicing requests. Each thread handles requests from a single client at a time and is isolated from other threads, using a Multi-Client Software Fault Isolation (MCSFI) scheme. Furthermore, CHANCEL supports various in-enclave services such as an inmemory file system and shielded client communication to ensure complete mediation of the program's interactions with the outside world. We implemented CHANCEL and evaluated it on SGX hardware using both micro-benchmarks and realistic target scenarios, including private information retrieval and product recommendation services. Our results show that CHANCEL outperforms a baseline multi-process sandbox by 4.06 − 53.70× on micro-benchmarks and 0.02−21.18× on realistic workloads while providing strong security guarantees.
The femtocell and the fractional frequency reuse (FFR) techniques respectively have received wide attention as the solutions to the data surge problem in mobile networks. With FFR, the frequency band of a macrocell is divided into several frequency partitions (FPs) and the transmission power levels assigned to FPs differ from each other. In this paper, we propose a downlink resource partitioning scheme for two-tier networks where macrocells adopting FFR are overlaid with the femtocells. With the proposed scheme, every FP is divided into the macro-dedicated, the shared, and the femto-dedicated portions. The ratio of these three portions is different for each FP. We suggest a method to determine a proper ratio of portions in each FP, by using optimization approach. Simulation results show that the proposed scheme maximizes the whole system capacity while satisfying the constraints on the minimum capacity requirement for both macrocell and femtocell.Index Terms-Femtocell, two-tier network, fractional frequency reuse, resource partitioning.
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