The purpose of this study was to examine the effectiveness of self-help groups in the rehabilitation of people recovering from mental illness. A qualitative approach was adopted, with individual interviews of 12 clients and four focus group interviews of 22 professionals and volunteers, in a Hong Kong self-help organization. Three major categories emerged from the client interviews: the meaning of self-help; experience of self-help group involvement; and changes in life. The major categories which emerged from the focus groups were: the meaning of self-help; therapeutic factors; therapeutic process; facilitators' expectation; and difficulties encountered. Results indicated that self-help group involvement provided positive experiences for the members and led to some changes in their lives which contribute to the rehabilitation of their illness. Meanwhile, the professionals' and volunteers' view of the use of self-help groups was found to coincide with previous literature. Moreover, a spiritual dimension was expressed by all respondents as one of the factors that enhanced the group cohesiveness. It was concluded that self-help group involvement is beneficial to psychiatric rehabilitation. Findings have implications for further utilization of self-help groups for the people recovering from mental illness, as an alternative form of health care to complement the inadequacies in the present health care system.
We have used site-directed spin labeling and pulsed dipolar electron-electron paramagnetic resonance (DEER) to resolve the structure and dynamics of flexible and disordered regions of myosin binding protein-C (MyBP-C)'s cardiac isoform, with implications for the pathophysiology of hypertrophic cardiomyopathy (HCM). N-terminal domains of cMyBP-C contain binding domains for several interaction partners in the myofilament, including myosin heavy chain subfragment 2 (S2) and actin. We engineered pairs of labeling sites in protein fragments of mouse cMyBP-C to measure with high resolution distance and disorder between (1) domains C0 and C1, flanking the flexible Pro/Ala-rich linker, and between (2) domains C1 and C2, flanking the partially disordered phosphorylation motif, using DEER. Changes in distance and disorder were assessed for double-Cys mutant cMyBP-C's free in solution and when bound to myosin S2 or actin, with or without cMyBP-C phosphorylation by protein kinase A (PKA). Understanding conformational transitions in the flexible and dynamic portions of cMyBP-C upon actin-myosin binding and phosphorylation provide new molecular insight into defining its modulatory role in muscle force development.
Depression is a common, depleting, and potentially life-threatening disorder. This pilot study examined the feasibility and applicability, reported preliminary evidence for effectiveness, and explored the potential healing mechanisms of a faith-based spiritual intervention for people with depression. The intervention consisted of six weekly sessions focused on restoring a connection with the divine, forgiveness and freedom, suffering and transcendence, hope, gratitude, and relapse prevention. Seven adults with mild or moderate depressive symptoms were recruited. A qualitative evaluation was conducted via focus group discussions, and rating scales were administered at baseline, after the intervention, and at the 3-month follow-up. The mean difference scores of the treatment’s effect over time were analyzed using Friedman’s ANOVA. The themes identified by the focus group included the meaning of the spiritual intervention, the effect of involvement in a spiritual group, and the therapeutic components. The results indicated a significant decrease in the mean scores for depression (PHQ-9) after intervention and at the 3-month follow-up. Participants expressed their improvement in terms of increased knowledge about depression, enhanced coping mechanisms, and improved self-esteem. The preliminary evidence suggested that the faith-based spiritual intervention was effective in reducing depressive symptoms and also helped participants develop a greater sense of connection with themselves, others, and their environment.
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