Abstract-Inflammatory response and chemotaxis of vascular wall cells play an important pathogenic role in the development of atherosclerosis. Monocyte chemoattractant protein-1 (MCP-1) is a potent chemoattractant for monocytes. Besides the induction of monocyte recruitment, it has been suggested that MCP-1 may directly activate smooth muscle cells. We investigated whether MCP-1 affects the proliferation and cytokine production of human vascular smooth muscle cells (VSMCs) and determined the underlying signal transduction pathways. Stimulation of VSMCs with MCP-1 induced proliferation and resulted in a concentration-and time-dependent release of the proinflammatory cytokine interleukin-6 (IL-6). Pretreatment with pertussis toxin, GF109203X, and pyrrolidine dithiocarbamate inhibited MCP-1-dependent IL-6 release, suggesting the involvement of G i proteins, protein kinase C, and nuclear factor-B (NF-B). MCP-1 also induced extracellular signal-regulated kinase, which, along with IL-6 release, was inhibited by pertussis toxin. Key Words: atherosclerosis Ⅲ monocyte chemoattractant protein-1 Ⅲ interleukin-6 Ⅲ nuclear factor-B Ⅲ activator protein-1

Abstract. The Depressive Experiences Questionnaire (DEQ; Blatt, D'Aflitti, & Quinlan, 1976 ) is a self-report questionnaire designed to differentiate between dependency and self-criticism, two personality traits associated with increased risk for psychopathology in general and depression in particular. Over the years, different shortened versions of the DEQ have been constructed, attempting to offer an alternative for the complex scoring procedure of the original DEQ. In this article, the authors studied the factorial validity of the original DEQ and of six shortened versions in a student sample (N = 636) and in a clinical sample (N = 404) by means of confirmatory factor analysis. Furthermore, the construct validity of the different versions of the DEQ was studied by computing correlations with different types of depressive symptoms and interpersonal problems. Dependency was hypothesized to be associated with somatic depressive symptoms and with nonassertive, overly accommodating, and self-sacrificing interpersonal behavior; self-criticism would be associated with cognitive depressive symptoms and with vindictive, cold, and socially inhibited interpersonal behavior. In the present study, the reconstructed DEQ ( Bagby, Parker, Joffe, & Buis, 1994 ) demonstrated the best psychometric properties. This factor model showed good fit to student and clinical (raw as well as ipsatized) data. Furthermore, intercorrelations between scores on dependency and self-criticism were adequately low (around .45) and the associations with different types of depressive symptoms and interpersonal characteristics were in line with theoretical predictions. Importantly, ipsatization of the DEQ scores was necessary to observe the hypothesized associations with depressive symptoms. Overall, the authors concluded that the reconstructed DEQ is a simple and valid scoring procedure with some important advantages compared to the more complex scoring procedures of the DEQ.

Medical students regarded psychological characteristics as generally interesting and important for medical care, but rarely considered specializing in these medical fields after graduation. Potential remedies (e.g., improved teaching of psychosocial competences and psychotherapeutic knowledge, career counselling) are discussed.

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Occupational exposure to patients with COVID-19 is a stress factor. The aim of this study was to assess gender differences in anger among medical hospital staff. N = 78 hospital employees completed State-Trait Inventory-2. Female personnel showed higher scores in the main “trait anger” scale and its subscale “anger temperament”, while “anger control-out” was significant lower. More specific training for female hospital staff could achieve health-related equality. Focusing on anger as a leading indicator could lead to better prevention and self-monitoring.