Co-culture with colchicine and/or stimulation with adenosine triphosphate (ATP) and lipopolysaccharide (LPS) led to a significant increase in receptor shedding. Neutrophils were not prevented from spontaneous shedding by blocking IL-1 or the NLRP3 inflammasome. In summary, the data demonstrate that ex vivo cultured neutrophils derived from FMF patients display a unique phenotype with spontaneous release of high amounts of IL-18, S100A12, MPO, caspase-1, and proteinase 3 and spontaneous activation as demonstrated by the loss of CD62L. Neutrophilic activation seems to be independent from IL-1 activation and displays a gene-dose effect that may be responsible for genotype-dependent phenotypes.
Im vorliegenden Artikel geht es um einen neuen Ansatz, wie Kinder in der Sekundarstufe Bilder im GW-Unterricht mehrperspektivisch und operativ auswerten können. Drei Lehrpersonen an einem Wiener Gymnasium haben die Methode der ‚Erweiternden Bildauswertung' in zwei ersten Klassen getestet, einander hospitiert und gecoacht. Die Methode EBAU und die empirischen Erfahrungen damit werden im mediendidaktischen Kontext vorgestellt.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.