Infertility affects nearly 50 million couples worldwide, with 40−50% of cases having a male factor component. It is well established that nutritional status impacts reproductive development, health and function, although the exact mechanisms have not been fully elucidated. Genetic variation that affects nutrient metabolism may impact fertility through nutrigenetic mechanisms. This review summarizes current knowledge on the role of several dietary components (vitamins A, B 12 , C, D, E, folate, betaine, choline, calcium, iron, caffeine, fiber, sugar, dietary fat, and gluten) in male reproductive health. Evidence of genenutrient interactions and their potential effect on fertility is also examined. Understanding the relationship between genetic variation, nutrition and male fertility is key to developing personalized, DNA-based dietary recommendations to enhance the fertility of men who have difficulty conceiving.
What ' s known on the subject? and What does the study add? Frenuloplasty, using common plastic surgical techniques for scar lengthening, is a commonly performed operation amongst urologists for isolated frenular pathology. However, there is very little data in the urological literature regarding either technique or assessment. The only other published study was a questionnaire follow-up with a 23% response rate and the technique used was not clarifi ed. Other studies describe expensive, rarely used procedures and are hampered by small patient numbers or short-term follow-up only.Our study validates the common practice of using plastic surgical techniques for scar lengthening. We have 100% clinical short-term follow-up (3 months) and 91% long-term follow-up (up to 10 years) showing high patient satisfaction scores and low complication and re-operation rates. This provides an evidence base from which to counsel patients who are keen for foreskin sparing surgery for frenular pathology.The extra addition of our grading system allows patients to be risk-stratifi ed as to the risk of re-operation depending on their status at presentation and underlying pathology.
OBJECTIVE• To assess the long-term patient satisfaction and outcomes for penile frenuloplasty when offered as an alternative to circumcision for frenular pain and/or scarring.
PATIENTS AND METHODS• Data was prospectively collected over 10 years, for a total of 106 men.• The nature of the frenular problem was graded.• Techniques of V-Y plasty, Z-plasty or a combination of the two were used.• All patients were reviewed at 3 months and contacted via questionnaire ≥ 1 year after surgery. The questionnaire assessed satisfaction, cosmetic appearance, pain on intercourse, need for subsequent surgery and if they would recommend the procedure to a friend.
RESULTS• Follow-up was 100% (106/106) at 3 months and 91% (96/106) ≥ 1 year.• Patient satisfaction and cosmesis scores both averaged 8.9/10.• Need for subsequent circumcision was 8% (9/96).• There were minor complications (bruising/infection/partial dehiscence) in 8% (9/96) of patients.• 97% (84/87) of patients would recommend the procedure to a friend.
CONCLUSIONS• Penile frenuloplasty is a safe alternative to circumcision.• There are high patient satisfaction rates after surgery.• Low numbers of patients require a completion circumcision after penile frenuloplasty.
KEYWORDSfrenuloplasty , circumcision , frenular pain Study Type -Therapy (case series) Level of Evidence 4
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.