These results suggest that specific inhibition of ASBT is a novel therapeutic approach for treatment of hypercholesterolemia resulting in a decreased risk for atherosclerosis. -
The 1,2-Benzothiazepines. -The title compounds of type (IX) are further modified by functional-group manipulation on the aryl residues. Some derivatives show nanomolar activities in vitro. -(TOLLEFSON*, M. B.; KOLODZIEJ, S. A.; FLETCHER, T.; VERNIER, W. F.; BEAUDRY, J. A.; KELLER, B. T.; REITZ, D. B.; Bioorg.
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