ResumenEl síndrome de Vogt-Koyanagi-Harada (VKH) es una entidad clínica caracterizada por panuveítis granulomatosa bilateral difusa. Cursa con desprendimiento exudativo de la retina y puede acompañarse de alteraciones del sistema nervioso central, dermatológicas y auditivas. Aunque es de etiología desconocida, es considerada como una enfermedad autoinmune asociada a los haplotipos HLA-DR4. Se divide en tres fases: prodrómica, oftálmica y de convalecencia. El diagnóstico se realiza mediante la historia clínica y examen físico-oftalmológico completo, así como también por exámenes complementarios como la angiografía retinal fluoresceínica y punción lumbar. El tratamiento se basa en el uso de corticoides tópicos y sistémicos, siendo de gran importancia la dosis inicial y la duración del tratamiento. A continuación se presenta un caso clínico de un paciente de sexo masculino que consulta por disminución de la agudeza visual de ambos ojos y micropsia; mediante criterios clínicos y exámenes complementarios se llegó al diagnóstico de síndrome de Vogt-Koyanagi-Harada en su variante incompleta; él se manejó con corticoterapia tópica y sistémica. Al mismo tiempo este artículo revisa la literatura relacionada con esta patología.PALABRAS CLAVE: desprendimiento de retina, síndrome uveomeningoencefálico, panuveítis, trastornos de la visión. AbstractThe Vogt-Koyanagi-Harada syndrome (VKH) is a clinical entity characterized by diffuse bilateral granulomatous pan-uveitis. It is presented with exudative retinal detachment and may be accompanied by dermatologic, auditory and central nervous system alterations. Although it is of unknown etiology, it is considered an autoimmune disease associated with HLA-DR4 haplotypes. It is divided into three phases: prodromal, ophthalmic and convalescence. Diagnosis is performed through clinical history and complete eye examination, as well as by additional tests such as fluorescein angiography and lumbar puncture. The treatment is based on the use of topical and systemic corticosteroids, being the initial dose and duration of treatment of great importance. A clinical case of a male patient who consulted for decreased visual acuity in both eyes and micropsia is presented; by clinical and complementary examinations the diagnosis was Vogt Koyanagi-Harada syndrome in its incomplete form. The patient was treated with topical and systemic corticosteroid therapy. At the same time, this article reviews the literature related to this disease.KEYWORDS: retinal detachment, uveomeningoencephalitic syndrome, panuveitis, vision disorders. ResumoA síndrome de Vogt-Koyanagi-Harada (VKH) é uma entidade clínica caracterizada por panuveíte granulomatosa bilateral difusa. Cursa com o desprendimento exsudativo da retina e pode ser acompanhado de alterações do sistema nervoso central, dermatológica e auditiva. Embora seja de etiologia desconhecida, é considerada uma doença autoimune associada com o haplotipo HLA-DR4. Ela é dividida em três fases: prodrômico, oftálmica e convalescença. O diagnóstico é feito pela histó...
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