The objective of the present study was to study the cytoarchitectural structure of the cervical and thoracic segments of thymus in alpaca (Lama pacos) fetuses. For this purpose, 10 fetuses between 40-190 days of gestation were collected form the local slaughterhouse. At day 40, the developing thymus has acinar cytoarchitectural morphology, infiltrated by a few lymphoid cells surrounded by mesenchymal cells. At day 60, the cervical segment looks like a «follicular» lymphoid, densely populated by thymocytes, whereas the thoracic region has a cystic appearance with short trabecular projections. Cortex and medulla differentiation starts in the posterior cervical and thoracic segments by day 100 and in the anterior cervical segments by day 130, and is well established by day 165. The thymic capsule remained as a double cellular layer of lax connective tissue. Subcapsular and trabecular blood vessels have fenestrated endothelium. Erythroblastic cells were observed by day 100 in the cortex and subcapsule zones. Medullar Hassall's corpuscles were observed by day 100, and the epithelial reticular cell barrier in the cortical medullar zone was observed by day 130. Key words: alpaca, fetus, thymus, Hassal corpuscle RESUMENEl objetivo del presente trabajo fue el estudio citoarquitectural de los segmentos cervicales y torácicos del timo en fetos de alpaca (Lama pacos). Se recolectaron 10 fetos entre 40 y 190 días de desarrollo para ser sometidos a estudio histológico. A los 40 días, el esbozo del timo tiene una morfología citoarquitectural de tipo acinar infiltrado por escasas células linfocíticas y rodeado por células mesenquimales. A los 60 días, el segmento cervical se presenta como un "folículo" linfoide densamente poblado por timocitos, mientras que la región torácica tiene una apariencia cavitaria con proyecciones trabeculares cortas. La diferenciación de corteza y médula se inicia en los segmentos cervicales posteriores y torácicos a los 100 días y en los segmentos cervicales anteriores a los 130 días. Todos los segmentos presentan disposición lobulillar bien definidos en corteza y médula a los 165 días. La cápsula tímica se mantiene principalmente como una doble capa celular con tejido conjuntivo laxo. Los vasos sanguíneos subcapsulares y trabeculares presentan endotelio fenestrado. Las células eritroblásticas se ubican en las zonas subcapsulares
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