Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic, recurrent inflammatory disease affecting skin that bears apocrine glands. It is characterised by the presence of tender subcutaneous nodules that may rupture, resulting in deep dermal abscesses, fibrosis with dermal contractures and induration of the skin. The management of HS is a challenge for physicians as the pathogenesis is not clearly defined and prevents the use and development of directed therapies. Treatment options are oral agents (antibiotics, immunomodulators) and surgical excision. Historically, surgical management has been complicated by difficult closure and high recurrent rates. In the last 10 years, negative pressure wound therapy (NPWT) has proven to be a great adjunct for wound management as it provides the adequate conditions for wound healing, promotes granulation and helps to control infection. Here, we report a case of severe perineal HS treated with radical excision and NPWT as an adjunct. The patient only had a recurrence 3 years after primary treatment and was surgically treated for cosmetic reasons without any complications. Finally, we present a review of the relevant literature.

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UVA-1 phototherapy can be an alternative for patients with severe atopic dermatitis even at lower doses than those described in other series (30 J/cm ) and not only for acute flares. Cumulative total dose is a variable that affects the clinical response directly. Large prospective studies are needed.

A 57-year-old man presented to the emergency department with a 12-hour history of hematuria. Intravenous urography was performed after the administration of iodinated contrast material. Several hours later, generalized pustular eruptions developed, with multiple coalescing vesicles and pus-filled bullae observed on the patient's face and ears (Panels A and B, respectively), his trunk, and his arms and legs. Laboratory studies indicated neutrophilia and mild eosinophilia (with 55% neutrophils and 8% eosinophils). The white-cell count was 6500 per cubic millimeter. Histopathological examination of the lesions revealed pseudoepitheliomatous hyperplasia, full-thickness epidermal necrosis, and a diffuse neutrophilic dermal infiltrate. The results of microbiologic studies were negative. On the basis of these findings, a diagnosis of iododerma was made. Iododerma is a hypersensitivity reaction to iodine. Although its pathogenesis is not understood, delayed iodine clearance and the induction of neutrophil degranulation have been proposed as mechanisms. Intravenous injection of iodinated contrast material is among the most common causes of iododerma; however, iododerma has also been reported after the oral or topical administration of iodine. Treatment with thalidomide was initiated, and the skin lesions completely resolved within 4 weeks. After careful evaluation, the cause of the hematuria was not identified. The hematuria resolved spontaneously within 3 days without treatment. The patient's kidney function remained normal.