In 1995, the U.S. Public Health Service (USPHS) and the Infectious Diseases Society of America (IDSA) developed guidelines for preventing opportunistic infections (OIs) among persons infected with human immunodeficiency virus (HIV); these guidelines were updated in 1997 and 1999. This fourth edition of the guidelines, made available on the Internet in 2001, is intended for clinicians and other health-care providers who care for HIV-infected persons. The goal of these guidelines is to provide evidence-based guidelines for preventing OIs among HIV-infected adults and adolescents, including pregnant women, and HIV-exposed or infected children. Nineteen OIs, or groups of OIs, are addressed, and recommendations are included for preventing exposure to opportunistic pathogens, preventing first episodes of disease by chemoprophylaxis or vaccination (primary prophylaxis), and preventing disease recurrence (secondary prophylaxis). Major changes since the last edition of the guidelines include 1) updated recommendations for discontinuing primary and secondary OI prophylaxis among persons whose CD4+ T lymphocyte counts have increased in response to antiretroviral therapy; 2) emphasis on screening all HIV-infected persons for infection with hepatitis C virus; 3) new information regarding transmission of human herpesvirus 8 infection; 4) new information regarding drug interactions, chiefly related to rifamycins and antiretroviral drugs; and 5) revised recommendations for immunizing HIV-infected adults and adolescents and HIV-exposed or infected children.

This work proposes a digital platform based in a multi-agent system to plot the different mobility alternatives to counteract the agglomerations in public transport and therefore decrease COVID-19 infections in the GDL. Following the recommendations of the World Health Organization (WHO) in the face of the health emergency of COVID-19, mainly keeping a healthy distance, the GDL can integrate sustainable mobility as the public bicycle system and reduce the users in regular transport routes to safe levels. For that endeavor, we develop an analysis of the behavior of the trips in the public transport of Guadalajara to explore the possibility of substituting the short transfers of bus travel by bicycle travels using the existing public bicycle infrastructure. We introduce a multi-agent simulation to plot different scenarios of mobility moving bicycles and buses. In this preliminary work, we show possibilities of the simulation integrating as variables not only the risk of COVID-19 infection but also the impact on economy and traffic reduction, CO2 Footprint, and health achieved with this multimodal mobility simulation. Also, the simulation can help to incentivize safer and efficient mobility strategies in the public transport system to reduce the use of private vehicles.

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La responsabilidad en cualquiera de sus esferas o especies no es una invención, es un imperativo; es lo mismo que decir un conjunto de actos irrenunciable, consistente, en primer orden, en la reflexión del mundo, de las instituciones, las acciones y de poner entre paréntesis las apreciaciones dadas precisamente sin reflexión. esta compilación diserta en torno a la responsabilidad social; hay en ella posturas, posiciones o, mejor, terrenos de enunciación desde los que los autores se ubican para reflexionar. Lo hacen porque desean que la responsabilidad social no sea una moda de un individuo, de un grupo de sujetos o de estructuras. Uno de tantos panfletos que hombres, grupos u organizaciones toman con actitud esnobista y solo con la intención de no perder.