This study is intended to determine the effects of system management on value creation and global growth in born startups. To achieve this, a survey was empirically carried out on 300 owners in born startups with less than five years’ experience. The findings are as follows. First, entrepreneurship, operation system, and support system as sub-variables of system management have a positive effect on value creation. Second, entrepreneurship and operating system have no significant effect on global growth, but the support system has a significant effect on global growth. Third, value creation has no significant mediating effect on global growth, which means that owners’ entrepreneurship can boost value creation as a corporate systematic operation when they have globally-oriented thinking, relationships through global network organization, the expertise of business, and some level of capital. In particular, their capability and expertise can be drivers to enter early global growth companies through value creation. Consequently, for the early value creation and global growth of born startups, they should recognize that system operation and value creation-oriented corporate global experience, due to their entrepreneurship as international companies under global market orientation, are key variables affecting a global born startup, and thus reflect them in management.