An increasing number of synthetic pyrethroids are used as an environmental friendly substitute of organophosphate and organochlorine insecticides. Pesticide pollution in the coastal ecosystem of Korea is considered to be a cause of slow growth and prevalence of diseases in commercial ¢shes. Therefore, it is necessary to develop fast techniques to detect insecticide toxicities. In the present work the results of rapid and inexpensive laboratory experiments show the patho-physiological alteration of blood parameters to sublethal concentration of pyrethroid insecticide (cypermethrin) in the commercially important Korean rock¢sh (Sebastes schlegeli). Cypermethrin-exposed ¢sh showed erythropenia, low haematocrit and haemoglobin content and hyperglycemia, especially for long-term exposure at high concentrations. Cypermethrin caused increased levels of serum glutamic-acid-oxylacetic-acid-transaminase, glutamic-acid-pyruvic-acid-transaminase and alkaline phosphatase, concomitant with a decreased concentration of chloride ion and blood serum osmolality, indicating the disruptive activity of cypermethrin after 8 weeks exposure. Moreover, reduced level of serum total protein, albumin, cholesterol, lysozyme activity and signi¢cantly higher level of glucose, bilirubin and malondialdehyde were measured and attributed to an increased demand for energy by ¢sh under stress to cope with detrimental conditions imposed by chronic exposure to the toxicant. Ã Values indicate mean AE SE. Aquaculture Research, 2005, 36, 898^905 Stress responses of rock¢sh induced by cypermethrin J-H Jee et al.
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