K.R.M and R.B.S. contributed equally to this studyMannan-binding lectin (MBL) circulates in plasma in complex with MBL-associated serine proteases (MASP) -1, -2 and -3 and a smaller component, MApI9. When MBL binds to the surface of foreign material (microorganisms), MASP-l, -2, -3 are activated. MASP-2 then activates the complement system. MASP-l and -3 may activate other (unidentified) systems. MBL levels, MBL-bound MASP-l and MBL-bound MASP-2 activities have been evaluated in healthy individuals from UK and Armenian populations. MBL-bound MASP-2 activity declines in aging (P
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