This unique paraneoplastic syndrome chiefly affecting the brainstem may be a diagnostic clue to the presence of unsuspected prostate adenocarcinoma. Further studies will be required to determine the precise antigenic target.
In the pivotal trials of natalizumab in the treatment of relapsing-remitting multiple sclerosis (AFFIRM and SENTINEL), a dramatic reduction in relapse rate, new or enlarging T2-hyperintense lesions, and mean number of gadolinium-enhancing lesions was observed. While both relapses and new MRI lesions were observed in these trials, there has been no comment on the presence of aggressive disease in the face of natalizumab treatment. I report a 31-year-old woman with relapsing remitting MS of 12 years duration who developed aggressive demyelinating disease four months after the initiation of natalizumab. The clinical worsening was accompanied by a significant increase in new large T2-hyperintense signal abnormalities and in both solid and C-shaped contrast-enhancing lesions. Neither the clinical severity nor the striking MRI abnormalities had been noted earlier in her disease course. Neutralizing antibodies to natalizumab were not detected. She subsequently responded to combination therapy of pulsed methylprednisolone and daily glatiramer acetate.
In mechanical-impact tests, the potential energy of the plummet is divided between energy absorbed by the specimen, the plummet's kinetic energy of rebound, and various losses in the test machine. Thus, all of the potential (or drop height) energy is not transferred to the specimen. The fracture and deformation characteristics and the reactability of metal specimens are dependent on the amount of energy that the specimen absorbs. The absorbed energy may be calculated either from knowledge of the potential energy and rebound height (assuming losses are negligible), or from the depth of striker-pin penetration into the specimen. The depth measurement gives an estimate of specimen strain; an estimate of force exerted on the specimen during deformation allows calculation of the work of deformation. The effects of the absorbed energy on fracture and deformation characteristics and on reactions in Al-Li alloys and alloy 2219 are discussed.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.