Twenty-nine patients received high-dose chemotherapy and autologous stem cell transplantation from June 1997 to December 1998. The number of CD34+ cells reinfused was 2.4 x 10(6) to 69.0 x 10(6)/kg. Twelve patients developed a fever in the immediate postengraftment period. One patient had a documented infection that could account for the fever; a second patient had a rash and biopsy proven acute graft-versus-host disease (GvHD) that responded to steroids. In the other 10 patients (30%) there was no identifiable cause of the fever. One of these patients received 4.2 x 10(6) CD34+ cells/kg. The other nine received 22.0 x 10(6) to 69.0 x 10(6) CD34+ cells/kg. In our series of 29 patients, 9 of the 11 (82%) patients who received > 20 x 10(6) CD34+ cells/kg developed fever in the postengraftment period. There was a significant association between the number of CD34+ cells (<20 vs. >20 x 10(6)) and occurrence of fever (odds ratio = 76.5; p = 0.00005). Even though they engrafted promptly (7 to 9 days), the fever required evaluation for infection, blood cultures, antibiotic treatment, and observation. This required additional hospitalization of 1 to 7 days. These data suggest that a high number of CD34+ cells is frequently associated with post-engraftment fever and prolongation of the hospital stay. Should there be an upper limit in the number of reinfused CD34+ cells is a question that has to be addressed and possibly studied.
Platelet concentrate samples from 100 units collected by apheresis at The American Red Cross Blood Bank located at Columbia, S.C. and from 31 units collected by apheresis at The Santa Barbara Tri-County Blood Bank located in Santa Barbara, California were sent overnight to Fishers, Indiana and tested for platelet factor 3 activity. The maximum dilution that would support normal clotting was determined for each unit. Units with maximum dilutions of 1:100 or greater were considered to have sufficient platelet factor 3 activity to be used for a transfusion. Ninety-six percent of the units sent from Columbia, South Carolina and 94.55% of the units sent from Santa Barbara, California were suitable for use based on their platelet factor 3 activity. This study shows the feasibility of sending platelet concentrates long distances and the importance of testing for platelet factor 3 activity.
New York -London 1982. VIII, 229 pp., e 12,-Residuals are uaed in many procedures designed to detect various types of disagreement between data and an eesumed model. This book is about diagnostics. The major emphaaia is on diagnostic tools for data analyses based on linear models in combination with least squarea methods of egtimation.I n chapter 2 diagnostic methoda using residuala are discussed. Especially the different tpyea of residuals which are important for diagnostica are defined and propertiee of these are proved.Besides these residuals the nuisance of several plota is stated. Also different transformations for the data are inveetigated. All these methods are useful for finding general inadequacies in a model. In chapter 3 the eseeeement of influence is considered. This influence analysis is discussed in details.Here the correspondence to the robustnees theory is to me. In chapter 4 aome alternative approaches to influence are considered. It is looked a t several methode that do not depend directly on the influence curve, but to use cme deletion pertubation schemes. It is considered a method based on the volume of confidence ellipsoids, another is due to ANDBEWB and PBEQIBON and this can be thought of aa a general omnibus diagnostic. The third discussed method beaee on the compari8dn of the predictive diatributions of future observations. In the chapter 6 it is diecutwed how diagnostic for linear least squarea regression might be extended to more complex situations. Here general definitione of reaiduals, a general approach to influence are given and disoueeed.This book gives a comprehensive course in diagnostics of regression. The book is written very clear, many examples help for understanding.H. Liiuter
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.