The aim of this paper is to determine the profile of acute alcohol poisoning and to estimate the risk of potentially adverse drug interactions (ADIs) in patients intoxicated by alcohol when attended in emergency care at hospital. A descriptive serial cross-sectional study was performed with 4,271 individuals intoxicated by alcohol, from January 2009 to July 2011. Possible correlations were measured by Pearson's chi-square test. The data show high consumption in the population, especially in males between 25 and 59 years. The main circumstances for poisoning were alcohol misuse (96.3%). After treatment complete recovery from the signs or symptoms of the poisoning was observed in 96.88% cases; and death in 0.70%. The demonstration of potential risk for ADIs in medical care included 300 medical records which contained a history of acute alcohol poisoning. Possible drug-drug interactions (44.2%) and drug-alcohol interactions (55.8%) were demonstrated in 60.60% of analyzed medical records. Among these cases, 3%, 92.4% and 4.6% were classified as mild, moderate and severe, respectively. The measurement of ADIs aims to prevent clinical complications in medical care for alcohol misuse disorders.Uniterms: Alcoholic intoxication. Emergency Medical Services. Risk Management. Medicines/adverse interactions/risk control. Medicines/alcohol interactions/risk control. O objetivo deste trabalho foi definir o perfil de intoxicação alcoólica aguda e estimar o risco de interações medicamentosas adversas (IMAs) potenciais em pacientes com intoxicação alcoólica atendidos na emergência hospitalar. Um estudo descritivo, serial, de corte transversal foi realizado com 4.271 indivíduos com intoxicação alcoólica, de janeiro 2009 a julho 2011. Correlações foram medidas pelo teste qui-quadrado. Os dados mostram alto consumo na população estudada, especialmente em homens de 25 a 59 anos. A principal circunstância de intoxicação foi o abuso (96,3%). Após tratamento, cura foi observada em 96,88% dos casos e morte em 0,7%. O risco de IMAs potenciais no atendimento médico incluiu 300 prontuários médicos com histórico de intoxicação alcoólica aguda. Possíveis interações medicamentosas (44,2%) e interações fármaco-álcool (55,8%) foram observadas em 60,6% dos prontuários analisados. Entre elas, 3%, 92,4% e 4,6% foram classificadas como leve, moderada e grave, respectivamente. A medição das IMAs visa a prevenir complicações clínicas no atendimento dos agravos devido ao abuso de álcool.Unitermos: Intoxicação alcoólica. Serviços Médicos de Emergência. Medicamentos/interações adversas/ controle de risco. Medicamentos/interação com álcool/controle de risco.
Mental disorder comorbidity in substance use disorder patients is a common problem with health care implications. This study aimed to investigate mental disorder comorbidity in a physical and mental health community-based care network specialized in alcohol and drug dependence. This multicenter crosssectional study included 103 substance use disorder patients from four Brazilian Referral Centers for Psycho-Social Care. Data were assessed by Mini International Neuropsychiatric Interview and Addiction Severity Index questionnaires. Unemployed single men between 30-59 years old characterized the sample and showed a significant correlation between alcohol, cocaine or crack, and cannabis dependence with some other serious mental disorders, but not among tobacco smokers. Mental disorder comorbidity is still common in some models of psychosocial care. It suggests that an unambiguous dual-diagnosis and a precise differentiation between primary mental disorders and substance use disorders must be a common clinical staff practice part of the routine in the different models of drug dependence care to obtain an effective mental health intervention for these individuals.
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