Both accuracy of WavSTAT alone and the algorithm combining HRE with WavSTAT proved to be insufficient for the in vivo differentiation of small colorectal lesions, and do not fulfill American Society for Gastrointestinal Endoscopy performance thresholds for assessment of diminutive lesions. Future studies should assess whether combining WavSTAT with more advanced imaging techniques could result in a higher accuracy.Netherlands Trial Registry (NTR 3235).

Introduction: This study aimed to gain insight into the real-world complexity of the challenges experienced by patients, their significant others, care professionals and the work and education environment concerning rheumatic diseases as well as the interrelation between these challenges; it also aimed to prioritise the identified challenges.Method: Using the Dialog Model, 21 people with various rheumatic diseases, 24 care professionals, 9 significant others, and 3 education and work representatives were asked about rheumatic disease-related challenges and needs in a series of focus groups and interviews. Data were inductively coded and analysed, resulting in a mind map thematically displaying the challenges. The mind map was translated into a survey, and respondents (N = 1802) prioritised themes and challenges.Results: Of the six identified themes, 'physical complaints' was prioritised the most, followed by 'collaboration in healthcare', 'social and mental wellbeing', 'self-management', 'information and options in healthcare' and 'work and education'. Challenges of people with rheumatic diseases appeared to be complexly interrelated. For instance, fatigue and pain affect everyday functioning, but can also heavily impact social and mental wellbeing. To facilitate support for these challenges, which many patients desire, patients and care professionals said that better collaboration between primary and secondary care professionals is needed. Additionally, patients felt that their experiential expertise deserves more acknowledgement from care professionals. Results were similar across different rheumatic diseases. Conclusion:Many patients desire more support to manage life with their disease. To facilitate this, collaboration and communication between healthcare professionals, and between healthcare professionals and individual patients, should be improved.

The evolving field of reproductive technologies greatly alters our practices of conception and pregnancy. It is thus crucial to develop such innovations in a democratic and sustainable manner through public participation. To date, participation has mostly focused on patients or health professionals deliberating on technological risks, benefits, costs, and healthcare experiences. Thereby, the opportunity is missed to consider broader social and moral implications. Speculative design has been presented as a promising way to open up deliberation on the impacts of new technologies. In this study, speculative design was used to gain insight into citizens’ views and concerns about the social and moral implications of the new reproductive technologies. Six themes of concern were found: the rights of the unborn; access and equality; social implications of individual choices; society as a community; ecology; and the value of wonder. Notably, the latter two issues are not commonly described in the participatory literature on reproductive technologies, indicating that speculative design is suitable for broadening the debate by including issues that have not been addressed yet. Furthermore, the study brought insight into the motivations and complex values that lie behind arguments in which the naturalness of reproductive practices is emphasized. A point of critical reflection is that to broaden the range of reflections probed by speculative design even more, both the designers and the audiences should become more diverse. If this is achieved, it is suggested using speculative design in the context of public deliberation with a more direct influence on innovation trajectories and as a means for the public to become more skilled in critically engaging with imagined futures.