Reported herein is the detection of iodine using a non‐covalent association complex formed between a β‐cyclodextrin host and a designer bimane ditriazole guest. This complex responds to the presence of iodine with a marked decrease in the observed fluorescence signal. A sub‐nanomolar detection limit of this system in the solution‐state was determined. Moreover, results using filter paper onto which the β‐cyclodextrin‐bimane complex was adsorbed show a noticeable advantage compared to the cyclodextrin‐free bimane. Thus, highly sensitive on‐paper colorimetric iodine detection was achieved.
An ultrasensitive fluorescent water sensor based on a dipodal bimane-Cu(II) complex is reported here. This complex, which is non-fluorescent in the absence of water, demonstrates a remarkable turn-on fluorescence in...
syn-α-Diiodobimane (syn-(R2,I)B) is a key intermediate for the derivatization of the bimane core in the α-positions. Here we describe an expeditious method to prepare symmetric α-bimane derivatives, such as syn-(R2,I)B, as well as unsymmetric ones. Our strategy turns the synthesis of α derivatives with extended π-systems practical and affordable. We applied this approach to the synthesis of ethynylbenzaldehyde bearing bimanes as potential selective probes for aldolase class I enzymes.
Reported herein is a fluorometric and colorimetric sensor for the presence of trace amounts of water in organic solvents, using syn-bimane based boronate ester 1. This sensor responds to the presence of water with a highly sensitive turn-off fluorescence response, with detection limits as low as 0.018% water (v/v). Moreover, analogously high performance was observed when compound 1 was adsorbed on filter paper, with the paper-based sensor responding both to the presence of liquid water and to humid atmospheres. Reusability of the paper-based sensor up to 11 cycles was demonstrated, albeit with progressive decreases in the performance, and 1H NMR and mass spectrometry analyses were used to explain the observed, hydrolysis-based sensor response.
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