Objectives
Thousands of food additives are being used by the food industries in ready to eat packed food. These food additives act as either preservatives or enhancers of palatability. Monosodium glutamate (MSG), a sodium salt of glutamic acid is a widely used food additive for enhancing taste. It gives the unique taste to the food called “Umami” or “Savory taste”, which is different from four primary tastes namely, sweet, sour, salty, and bitter. The current experimental study was investigated by dose-related effects of MSG on adult Wistar rats using histological and histomorphometric techniques.
Methods
Twenty-eight adult Wistar rats were divided into four groups i.e.; one control and three experimental groups. Rats were administered orally with different doses of MSG to the experimental groups and distilled water to the control groups consecutively for 45 days. At the end of the study, rats were sacrificed and tissues were collected for the examination.
Results
Histomorphometric data of the nuclei diameter of hepatocytes showed significant variation between control and experimental groups. Less PAS-positive material found in a higher dose of MSG-induced rats in histochemical observation.
Conclusions
One of the challenges of the problem of animal experimental studies is the application of results to human dietary intake of MSG. Based on the dose-dependent findings of the current study; it is evident that the administration of MSG is hepatotoxic in adult Wistar rats.
To study sperm vitality in fertile and infertile males, analyze and correlate. MATERIALS AND METHODS: Total 100 semen samples were studied in each of the experimental and control groups. Sperm vitality was determined by the dye-exclusion test. RESULTS: The percentage of vital spermatozoa in the control group was more than 74% in all the cases which was within the normal limits. However only 65 cases out of the total 100 in experimental group, showed the vitality percentage within normal limits (>74%). In 35 samples of the experimental group, the vitality percentage was in the range of 60 to 73%. The mean vitality percentage of the experimental group was 82 ±6.78 and that for the control group was 84.45. The difference in the mean and median values of vitality in the two groups was statistically significant. CONCLUSION: Sperm vitality was highly significantly more in semen samples of fertile males than those of infertile males.
Migraine, a major public health problem, occurring due to the consequences of serial changes in the nerve ganglion leading to an imbalance in the excitation and inhibition. The is the major neurotransmitter in the central nervous system, causing to the sensory neurons leading to sensitization and . The present study was done to determine the effects of on the Nr2B of NMDA receptors after inducing a migraine. The rats were treated with after inducing migraine with nitroglycerin 10mg/kg. The nitroglycerin treated rats showed intense staining for NR2B , and there was a decrease in the expression after treatment. This study concludes that the NR2B are during migraine and can be used to control those by its property.
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