Two experiments were conducted to evaluate the efficacy of dietary FERMKIT, a commercial toxin binder consisting of probiotic-fermented natural product containing chitin, chitosan and chitosan oligosaccharides (FERMKITO , EASY-BIO SYSTEM, Inc., Korea), in binding aflatoxin (AF) and zearalenone (ZEN) and ameliorating their mycotoxicity in meat type ducks. FERMKIT was supplemented to AF contaminated diets (at 120 ppb) at either 0.3 or 0.6% in experiment 1 and to ZEN contaminated diets (at 150 ppb) at 0.6% in experiment 2. In experiment 1 body weight gains were reduced by 37% and mortality was increased by 18% in ducks fed diet contaminated with AF at 120 ppb compared to ducks fed control diet (<10 ppb AF) for the 4-wk experimental period. However, dietary FERMKIT supplementation effectively alleviated overall toxicity induced by AF. The significant treatment-related changes in feather growth, web-toe hemorrhage, leg deformity, liver paleness, organ weights, hematological values and serum biochemical values, as compared to the control, were observed. The FERMKIT supplementation significantly diminished the adverse effects of AF and restored all the parameters measured back (<0.05) toward the control values. These findings indicated that FERMKIT, when added at the levels of 0.3 or 0.6% in the 120 ppb AF diets, could modulate the toxicity of AF with percentage sorption capacity of 52.70% at the level 0.3% and 79.85% at the level 0.6% of the diets (experiment 1). In experiment 2, FERMKIT, when added at 0.6% to the 150 ppb ZEN diets for the 4-wk experimental period, diminished the toxicity as shown by body weight gain, weights of testicles, oviducts, Bursa of Fabricius and cloaca eversion score as compared with the controls (<10 ppb ZEN) and 150 ppb ZEN diet with no added FERMKIT. The findings indicated that FERMKIT could be protective against the effects of ZEN in young growing ducks with percentage sorption capacity of 67.11% as evaluated from toxicity index parameter measured when added at 0.6% of the diets containing 150 ppb ZEN.
The aim of the present experiment was to evaluate the efficacy of a hydrate sodium calcium aluminosilicate and yeast cell wall (Fixar® Viva Dry) to prevent aflatoxin toxicity in meat-type ducks. In total, 336 1-day-old Cherry Valley ducks were randomly assigned to seven dietary groups, including of three diets without adsorbent. These included <30 (control), 60 and 120 μg/kg of aflatoxin in the diet and 60 or 120 μg/kg of aflatoxin supplemented with Fixar® Viva Dry at either 0.05% or 0.10% in the diet. Each treatment group was duplicated, with 24 birds per pen (replicate) throughout the 28-day trial period. The results showed that, bodyweight gain was reduced by 11% and mortality was increased by 10% in ducks fed diet containing aflatoxin at 120 μg/kg, compared with the control diet. However, dietary Fixar® Viva Dry supplementation effectively alleviated the overall toxicity induced by aflatoxin. Significant negative treatment-related changes were observed in feather growth, eye necrosis, web-toe haemorrhage, leg deformity, tibia bone porosity, liver paleness and fat content, organ weight and serum biochemical characteristics, as well as decreased leaked enzymes in blood serum, compared with the control. Addition of Fixar® Viva Dry in the diet significantly (P < 0.05) reduced the adverse effects of aflatoxin on all parameters measured, near to those in the control group. This finding indicated that Fixar® Viva Dry, when added at the level of 0.05% in 60 μg/kg or of 0.10% in 120 μg/kg aflatoxin diets, could modulate the toxicity of aflatoxin. In conclusion, these results showed that Fixar® Viva Dry 0.05% was effective in preventing the toxic effects of aflatoxin that may be present in poultry diets.
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