BackgroundDespite the increase in cancer incidence in the last years in Serbia, no nation-wide, population-based cancer epidemiology data have been reported. In this study cancer incidence and mortality rates for Serbia are presented using nation-wide data from two population-based cancer registries. These rates are additionally compared to European and global cancer epidemiology estimates. Finally, predictions on Serbian cancer incidence and mortality rates are provided.MethodsCancer incidence and mortality was collected from the cancer registries of Central Serbia and Vojvodina from 1999 to 2009. Using age-specific regression models, we estimated time trends and predictions for cancer incidence and mortality for the following five years (2010–2014). The comparison of Serbian with European and global cancer incidence/mortality rates, adjusted to the world population (ASR-W) was performed using Serbian population-based data and estimates from GLOBOCAN 2008.ResultsIncreasing trends in both overall cancer incidence and mortality rates were identified for Serbia. In men, lung cancer showed the highest incidence (ASR-W 2009: 70.8/100,000), followed by colorectal (ASR-W 2009: 39.9/100,000), prostate (ASR-W 2009: 29.1/100,000) and bladder cancer (ASR-W 2009: 16.2/100,000). Breast cancer was the most common form of cancer in women (ASR-W 2009: 70.8/100,000) followed by cervical (ASR-W 2009: 25.5/100,000), colorectal (ASR-W 2009: 21.1/100,000) and lung cancer (ASR-W 2009: 19.4/100,000). Prostate and colorectal cancers have been significantly increasing over the last years in men, while this was also observed for breast cancer incidence and lung cancer mortality in women. In 2008 Serbia had the highest mortality rate from breast cancer (ASR-W 2008: 22.7/100,000), among all European countries while incidence and mortality of cervical, lung and colorectal cancer were well above European estimates.ConclusionCancer incidence and mortality in Serbia has been generally increasing over the past years. For a number of cancer sites, incidence and mortality is alarmingly higher than in the majority of European regions. For this increasing trend to be controlled, the management of risk factors that are present among the Serbian population is necessary. Additionally, prevention and early diagnosis are areas where significant improvements could still be made.
The main objective of this study is to emphasize the basic climate modificators and types in Montenegro. Rarely could you find such a small area with more climate types and several subtypes and varieties as it is the case here. The most important climate modificators in Montenegro have been discussed in the Part One of the study, such as: mathematical - geographical position, relief dissection, atmospheric circulation and the Adriatic Sea. Atlantic and Mediterranean aquatories and Eurasian landmass play an important part in climate modification in the area of Montenegro. These vast areas represent the source of atmospheric action centres and air masses. In the Part Two of this study, the climate regionalization of Montenegro is given according to the K?ppen criteria, as it has been proved that it gives a good basis for solving several practical and scientific problems.
Medication non-adherence is associated with almost 200,000 deaths annually and €80–125 billion in the European Union. Novel technological advances (smart pill bottles, digital inhalers and spacers, electronic pill blisters, e-injection pens, e-Health applications, big data) could help managing non-adherence. Healthcare professionals seem however inadequately informed about non-adherence, availability of technological solutions in daily practice is limited, and collaborative efforts to push forward their implementation are scarce. The European Network to Advance Best practices and technoLogy on medication adherencE (ENABLE, COST Action 19132) aims to 1) raise awareness of adherence enhancing solutions, 2) foster knowledge on medication adherence, 3) accelerate clinical application of novel technologies and 4) work collaboratively towards economically viable policy, and implementation of adherence enhancing technology across healthcare systems.
Changes in Europe's Temperature Extreme Values. In environmental researches several concerns on the evolution of temperatures. However, in the last decade we can observe intensification of extreme events, including that of temperatures. The present research investigates the evolution of extreme temperature values scaled at annual scale using frequency analysis on historical data. Three types of extreme temperatures were analyzed: annual minimum and maximum, and highest daily temperature fluctuation on annual scale. The results show both the dynamics of changes and probabilistic laws describing the extreme values, obtaining hazard related to these phenomena. We found risky evolutions in case of maximum annual temperatures, when in 55% of locations the associated hazard value was increasing for long or short time period, and in case of highest daily temperature fluctuation, when in 71% of cases the associated hazard value was increasing for long or short time period.
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