The public health importance of the endophilic mosquito Aedes aegypti increased dramatically in the recent decade, because it is the vector of dengue, chikungunya, Zika and yellowfever.Theuseoflong-lastinginsecticidalnets(LLINs)fixedondoorsandwindows, as insecticide-treated screening (ITS), is one innovative approach recently evaluated for AedescontrolinSouthMexico.From2009to2014,cluster-randomisedcontrolled trials were conducted in Acapulco and Merida. Intervention clusters received Aedes-proof houses ('Casas a prueba de Aedes')withITSandwerefollowedupduring2years.Overall, resultsshowedsignificantandsustainedreductionsonindooradultvectordensitiesin thetreatedclusterswithITSafter2years:ca.50%onthepresence(OR≤0.62,P<0.05) andabundance(IRR≤0.58,P<0.05).ITSondoorsandwindowsare'user-friendly'tool, withhighlevelsofacceptance,requiringlittleadditionalworkorbehaviouralchangeby householders.Factorsthatfavouredtheseinterventionswere(a)houseconstruction,(b) highcoverageachievedduetotheexcellentacceptancebythecommunityand(c)collaboration of the vector control services; and only some operational complaints relating to screen fragility and the installation process. ITS is a housing improvement that should be part of the current paradigms for urban vector-borne disease control.infections and reducing the global burden of malaria [8] but also can be effective for lymphaticfilariasis,Japaneseencephalitisandotherarboviruses [9].TheuseofLLINsisconsideredahighlyeffective,safe,affordable,low-tech,long-lastingand simpleinterventionwitheffectsbothattheindividual(i.e.bednetspreventingthevectorfrom blood feeding) and community levels (i.e. by reducing the vector lifespan and population). Dengue -Immunopathology and Control Strategies 94Dengue -Immunopathology and Control Strategies 104