Nonobese diabetic (NOD) mice spontaneously develop an acute onset of hyperglycemia reminiscent of human type I diabetes. The disease is the end result of a mononuclear cell infiltration of pancreatic islets (insulitis), culminating in the selective destruction of islet beta-cells by autoreactive T-cells. NOD mice also exhibit defects in B-cell tolerance as manifested by the presence of autoantibodies against islet cell autoantigens. Based on the potential ability of B-cells to act as antigen presenting cells, we hypothesized that autoreactive B-cells of NOD mice may be necessary for the activation of islet reactive CD4+ T-cells. In the present study, we utilized an anti-mu antibody to induce in vivo depletion of B-cells and found that B-cell depletion completely abrogates the development of insulitis and sialitis in NOD mice. In contrast, control IgG-treated NOD mice developed insulitis and sialitis by 5 weeks of age. Additionally, the discontinuation of anti-mu chain antibody treatment led to the full restoration of the B-cell pool and the reappearance of insulitis and sialitis. Thus, we conclude that B-cells are a requisite cell population for the genesis of the inflammatory lesions of the islets of Langerhans. This finding suggests that autoreactive B-cells may act as the antigen presenting cells necessary for the initial activation of beta-cell-reactive CD4+ T-cells implicated in the pathogenesis of autoimmune diabetes.
We present an overview and first results from a M-band spectroscopic survey of planet-forming disks performed with iSHELL on the Infrared Telescope Facility, using two slits that provide resolving power R ≈ 60,000–92,000 (5–3.3 km s−1). iSHELL provides a nearly complete coverage at 4.52–5.24 μm in one shot, covering >50 lines from the R and P branches of 12CO and 13CO for each of multiple vibrational levels, and providing unprecedented information on the excitation of multiple emission and absorption components. Some of the most notable new findings of this survey are: (1) the detection of two CO Keplerian rings at <2 au (in HD 259431), (2) the detection of H2O rovibrational lines at 5 μm (in AS 205 N), and (3) the common kinematic variability of CO lines over timescales of 1–14 yr. By homogeneously analyzing this survey together with a previous survey of cooler stars, we discuss a unified view of CO spectra where emission and absorption components scan the disk surface across radii from a dust-free region within dust sublimation out to ≈10 au. We classify two fundamental types of CO line shapes interpreted as emission from Keplerian rings (double-peak lines) and a disk surface plus a low-velocity part of a wind (triangular lines), where CO excitation reflects different emitting regions (and their gas-to-dust ratio) rather than just the irradiation spectrum. A disk+wind interpretation for the triangular lines naturally explains several properties observed in CO spectra, including the line blueshifts, line shapes that turn into narrow absorption at high inclinations, and the frequency of disk winds as a function of the stellar type.
The incidence of postoperative hemorrhage following thyroid surgery stands at 1%-2 %. This low incidence contrasts with the significant potential complications of postoperative hemorrhage. Influencing factors and measures mentioned in the literature and own studies are discussed. Although an improvement in the postoperative hemorrhage rate was to be expected indirectly due to the increasing use of coagulation-relevant medication, there has been neither an increase in incidence nor a reduction in resultant complications, including primarily recurrent vocal cord paresis, tracheotomy and mortality. Factors that influence surgical success include a meticulous technique and caution, as well as ensuring intensive and qualified postoperative monitoring for a minimum of 4-6 h, thereby permitting immediate revision surgery at any time.
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