A series of 8‐bromo‐4‐oxo‐3‐quinolinecarboxylic acids was prepared via the borate ester, 8. The key intermediate in the synthesis of the final products 10a‐10d was 3‐bromo‐2,4,5‐trifluorobenzoic acid (3), conveniently prepared in two steps from the known oxazoline, 1. The preparation of 10a‐10d is a significant improvement of the literature procedure currently available for the synthesis of these compounds.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.