No abstract

COVID -19 is the most recent pandemic disease that has affected the world's population. We, as health care providers should be more responsible for reducing the transmission of this deadly disease. The aim of the survey was to assess the knowledge and awareness among dental professionals towards COVID -19 and reduce the spread among patients and co-workers. A cross-sectional study was conducted in a sample of 100 dental students by means of a questionnaire, using google forms, results were tabulated and analysed using SPSS. 24.8% prefer and rely on the fact that fever has been the main symptoms of COVID -19 while 32.7% of the respondents prefer on the fact that cough has been the symptoms leading to COVID -19 64% of the dental students are aware on the fact that patients should be checked on their temperature before the consultation. 36.3% of the dental students prefer no checking of temperature before the consultation. The results of the survey showed that some knowledge gaps exist among dental students regarding this very deadly disease and hence is an urgent need for training and conduct complete awareness regarding this deadly disease and control it by essential precautionary methods.

Engineered cell-based therapeutics is having a great commitment in the field of treatment of human diseases. Scientific studies revealed that cell-based therapeutics play a key role in the treatment of cancers which can be an alternative for traditional immunotherapy. Even though there have been promising results, and the potential side effects resulting in mortality forced the scientists to impart regulations in the current therapies. These are evident in the growing frame of the literature of synthetic biology. Synthetic Biology empowered these new approaches to several applications in the medical field, including the development of bioengineered cell-based immunotherapies, peculiarly T-cell engineering with tumour-targeting receptors and the Chimeric Antigen Receptor (CAR)-T cells. The specific applications of this bioengineering of cells include direct injection of cells, merging the cells with a biomaterial scaffold in an in vitro or situ condition, or the biomaterial scaffold implantation alone which can induce surrounding cells leading to tissue restoration. Hence the aim of this review article is to highlight the various aspects of engineered cell-based therapeutics.