499ine is of the same order in both mice and rats. Since the same general picture was obtained in both experiments with mice, it seems reasonable to assume that the effect of the methoxinine is ,to )reduce the caloric intake, which restriction alone is capable of reducing the liver lipids to a level as low as the values obtained with choline or methionine. In the Swiss animals, an equivalent quantity of methionine offsets the effect of methoxinine. In the C3H mice, more methionine Seems to be required. This is in line with our observatiuns(4) that the C3H mice do not respond as well as Swiss mice to diets that are low in methionine, suggesting a higher requirement of the former far methionine (or protein). The basal diet, while affecting only the liver in the mouse, produced the complete 4. Travers, J. J., and Cerecedo, L. R., unpublished data.choline deficiency syndrome in the weanling rat, that is, fatty liver, hemorrhagic kidneys, and intraocular hemorrhages. Littermate rats, which received methoxinine, had normal kidneys and eyes on gross examination, even though the large yellow livers indicated higher liver lipid values than were seen in the animals on the basal diet. When other littermates were fed methionine, in addition to methoxinine, the livers appeared nearer to normal.Conclusions. 1. In mice, methoxinine causes a reduction in the food consumption and a weight loss. 2. The toxic effects of methoxinine are alleviated by methionine. 3. Methoxinine is not lipotropic in mice, since the caloric restriction imposed by its ,toxicity can completely account for its "apparent" lipotropic activity .Recent observations on 'the ability of intravaginally instilled vitamin A to partially counteract vaginal cornification induced by estrogen( 1) have led us to reconsider the implication of McCullough and Dalldorf's suggestion ( 2 ) that local vitamin A deficiency is responsible for all epithelial keratinization ( including that accompanying metaplasia) .In particular, we were interested in investigating the possible role of local vitamin A inadequacy in normal epidermal keratiniza-*tion and any interrelation between vitamin A and estrogen in this process. A relation between vitamin A and excessive epidermal keratinization has been established by observations on the syndrome of follicular hyperkeratosis accompanying vit A deficiency in man(3-5) and in Ithe rat(6). In addition, a beneficial effect on wound healing has been reported both for vit A and for cod liveroil (7-10). However, more recently Brush 3. Lowenthal, L.
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