Background: Patients with pre-existing severe mental disorders are significantly less likely to receive guideline-recommended cancer treatment and seems to have a significantly lower rate of cancer survival compared to patients with cancer without mental disorders. Aim:To perform a systematic review on barriers at patient-, provider-and systemlevels in cancer trajectories of patients with pre-existing severe mental disorders.Method: A systematic review was performed following the PRISMA guidelines (PROSPERO ID: CRD42022316020).Results: Nine eligible studies were identified. Barriers at patient-level included lack of self-care and ability to recognize physical symptoms and signs. Provider-level barriers included stigma from health care professionals on mental disorders, whereas system-level barriers included fragmented health care and consequences of this. Conclusion:This systematic review found that barriers at patient-, provider-and system-levels exist in cancer trajectories for patients with severe mental disorders,This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
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