Background:The biological function and biochemical activity of mammalian stanniocalcin-2 are unknown. Results: Stanniocalcin-2 inhibits proteolytic release of insulin-like growth factor (IGF), and its ability to cause growth retardation upon transgenic overexpression in mice depends on its proteinase inhibitory function. Conclusion: Stanniocalcin-2 is a novel component of the IGF axis. Significance: Altered stanniocalcin-2 expression may affect IGF signaling under pathological conditions.
Background: The molecular mechanisms behind previously reported biological effects of stanniocalcin-1 are poorly understood. Results: Stanniocalcin-1 potently inhibits the proteolytic activity of the metzincin metalloproteinases PAPP-A and PAPP-A2, which promote insulin-like growth factor (IGF) activity in tissues. Conclusion: Stanniocalcin-1 is a novel proteinase inhibitor. Significance: Altered stanniocalcin-1 expression may affect IGF signaling in vivo under normal or pathological conditions.
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