Background: DNA polymerase II (PolII), the homologue of mammalian DNA polymerase e, is essential for chromosomal DNA replication in the budding yeast Saccharomyces cerevisiae and also participates in S-phase checkpoint control. An important issue is whether chromosomal DNA replication in other eukaryotes, including the fission yeast Schizosaccharomyces pombe-in which the characteristics of replication origins are poorly defined-also requires DNA polymerase e. It has been shown that DNA polymerase e is not required for the in vitro replication of SV40 DNA by human cell extracts.
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