Tetrazole derivatives R 0310New Cleavable Isocyanides for the Combinatorial Synthesis of α-Amino Acid Analogue Tetrazoles. -A four-component Ugi reaction to give tetrazoles (IV) includes cleavable isocyanides (I) and (VI). Treatment of the resulting products with an alkoxide produces 5-substituted tetrazoles in a convenient manner. The process is amenable to combinatorial synthesis. -(MAYER*, J.; UMKEHRER, M.; KALINSKI, C.; ROSS, G.; KOLB, J.; BURDACK, C.; HILLER, W.; Tetrahedron Lett. 46 (2005) 43, 7393-7396; Priaton GmbH, D-82327 Tutzing, Germany; Eng.) -Mais 04-123
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