IMPORTANCEThe monoclonal antibody combination of casirivimab and imdevimab reduced viral load, hospitalization, or death when administered as a 1200-mg or greater intravenous (IV) dose in a phase 3 COVID-19 outpatient study. Subcutaneous (SC) and/or lower IV doses should increase accessibility and/or drug supplies for patients. OBJECTIVE To assess the virologic efficacy of casirivimab and imdevimab across different IV and SC doses compared with placebo. DESIGN, SETTING, AND PARTICIPANTS This phase 2, randomized, double-blind, placebocontrolled, parallel-group, dose-ranging study included outpatients with SARS-CoV-2 infection at 47 sites across the United States. Participants could be symptomatic or asymptomatic; symptomatic patients with risk factors for severe COVID-19 were excluded. Data were collected from December 15, 2020, to March 4, 2021. INTERVENTIONS Patients were randomized to a single IV dose (523 patients) of casirivimab and imdevimab at 300, 600, 1200, or 2400 mg or placebo; or a single SC dose (292 patients) of casirivimab and imdevimab at 600 or 1200 mg or placebo. MAIN OUTCOMES AND MEASURES The primary end point was the time-weighted average daily change from baseline (TWACB) in viral load from day 1 (baseline) through day 7 in patients seronegative for SARS-CoV-2 at baseline. RESULTS Among 815 randomized participants, 507 (282 randomized to IV treatment, 148 randomized to SC treatment, and 77 randomized to placebo) were seronegative at baseline and included in the primary efficacy analysis. Participants randomized to IV had a mean (SD) age of 34.6 (9.6) years (160 [44.6%] men; 14 [3.9%] Black; 121 [33.7%] Hispanic or Latino; 309 [86.1%] White); those randomized to SC had a mean age of 34.1 (10.0) years (102 [45.3%] men; 75 [34.7%] Hispanicor Latino; 6 [2.7%] Black; 190 [84.4%] White). All casirivimab and imdevimab treatments showed significant virologic reduction through day 7. Least-squares mean differences in TWACB viral load for casirivimab and imdevimab vs placebo ranged from -0.56 (95% CI; -0.89 to -0.24) log 10 copies/mL for the 1200-mg IV dose to -0.71 (95% CI, -1.05 to -0.38) log 10 copies/mL for the 2400-mg IV dose. There were no adverse safety signals or dose-related safety findings, grade 2 or greater infusionrelated or hypersensitivity reactions, grade 3 or greater injection-site reactions, or fatalities. Two serious adverse events not related to COVID-19 or the study drug were reported.

The mrp are public expression of a special and exceptional historical moment of the Spain of the educational transition (1970-1985). They are close and are twinned with other social movements that work with great vitality in a very

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Resumen: Este artículo ofrece una explicación histórica y genética de la Inspección Educativa en España, desde sus orígenes en el siglo xix hasta la actualidad. La Inspección Escolar, función necesaria y organismo imprescindible de un sistema educativo contemporáneo, solo puede explicarse desde el contexto socioeducativo al que sirve, desde las grandes leyes de educación que definen la política educativa de un país, hasta su concreción en la cultura escolar de un establecimiento educativo. Al mismo tiempo, en este trabajo se reflexiona históricamente sobre la construcción de la profesión de inspector y supervisor, desde su formación, la articulación asociativa, la vinculación a la producción científica en pedagogía, publicaciones y revistas propias de sus asociaciones o del cuerpo de inspectores. Se plantean, finalmente, algunos de los retos a que tiene que hacer frente la Inspección Escolar en los inicios del siglo xxi. Palabras clave: Inspección; supervisión; educación; España; cultura escolar; historia.Abstract: This paper offers a historical and genetic answer of the educational supervision in Spain, from its origins in the 19th century to the present. The school supervision, necessary function and essential organism of a contemporary educational system, can only be explained from the socioeducational context it serves, from the great laws of education that define the educational policy of a country, to its concretion in the school la inspección educativa y la cultura escolar en españa. génesis, 60 proceso constituyente y actualización de funciones josé maría hernández díaz © EdicionEs UnivErsidad dE salamanca Aula, 25, 2019, pp. 59-89 la inspección educativa y la cultura escolar en españa. génesis, proceso constituyente y actualización de funciones 61 josé maría hernández díaz © EdicionEs UnivErsidad dE salamanca Aula, 25, 2019, pp. 59-89 la inspección educativa y la cultura escolar en españa. génesis, 62 proceso constituyente y actualización de funciones josé maría hernández díaz © EdicionEs UnivErsidad dE salamanca Aula, 25, 2019, pp. 59-89 la inspección educativa y la cultura escolar en españa. génesis, proceso constituyente y actualización de funciones 63 josé maría hernández díaz © EdicionEs UnivErsidad dE salamanca Aula, 25, 2019, pp. 59-89

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