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In response to the recent article by Rubio-Muñiz et al, and in agreement with the title of their interesting work (Monkeypox: is topical cidofovir a good idea?1), we consider that topical cidofovir is a valuable option for skin lesions caused by Mpox based on our recent publication by Sobral-Costas et al (Human monkeypox outbreak: epidemiological data and therapeutic potential of topical cidofovir in a prospective cohort study).