This research study focuses on the modeling and simulation of a gas distribution pipeline network with a special emphasis on gas ducts. Gas ducts are the most important components of such kind of systems since they define the major dynamic characteristics. Isothermal, unidirectional flow is usually assumed when modeling the gas flow through a gas duct. This paper presents two simplified models derived from the set of partial differential equations governing the dynamics of the process. These models include the inclination term, neglected in most related papers. Moreover, two numerical schemes are presented for the integration of such models. Also, it is shown how the pressure drop along the pipe has a strong dependency with the inclination term. To solve the system dynamics through the proposed numerical schemes a based MATLAB-Simulink library was built. With this library it is possible to simulate the behavior of a gas distribution network from the individual simulation of each component. Finally, the library is tested through three application examples, and results are compared with the existing ones in the literature.

As advanced Cloud services are becoming mainstream, the contribution of data centers in the overall power consumption of modern cities is growing dramatically. The average consumption of a single data center is equivalent to the energy consumption of 25.000 households. Modeling the power consumption for these infrastructures is crucial to anticipate the effects of aggressive optimization policies, but accurate and fast power modeling is a complex challenge for high-end servers not yet satisfied by analytical approaches. This work proposes an automatic method, based on Multi-Objective Particle Swarm Optimization, for the identification of power models of enterprise servers in Cloud data centers. Our approach, as opposed to previous procedures, does not only consider the workload consolidation for deriving the power model, but also incorporates other non traditional factors like the static power consumption and its dependence with temperature. Our experimental results shows that we reach slightly better models than classical approaches, but simultaneously simplifying the power model structure and thus the numbers of sensors needed, which is very promising for a short-term energy prediction. This work, validated with real Cloud applications, broadens the possibilities to derive efficient energy saving techniques for Cloud facilities.

Discrete Event Specification (DEVS) environments are implemented over middleware systems such as HLA, RMI, CORBA and others. DEVS exhibits concepts of systems theory and modeling and supports capturing the system behavior from the physical and behavioral perspectives. Further, they are implemented using object-oriented languages like Java and C++. This research work uses the Java platform to implement DEVS over a Service Oriented Architecture (SOA) framework. Called the DEVS/SOA, the framework supports a development and testing environment known as DEVS Unified Process that is built on a model continuity-based lifecycle methodology. DEVS Unified Process allows DEVS-based Modeling and Simulation (M&S) over net-centric platforms using DEVS/SOA. This framework also provides the crucial feature of run-time composability of coupled systems using SOA. We describe the architecture and designs of the server and the client. The client application communicates with multiple servers hosting DEVS simulation services. These simulation services are developed using the proposed symmetrical services architecture wherein the server can act as both a service provider and a service consumer contrary to the unidirectional client—server paradigm. We also discuss how this services-based architecture provides solutions for cross-platform distributed M&S. We demonstrate the DEVS/SOA framework with a scenario of Joint Close Air Support specified in Business Process Modeling Notation (BPMN). We also provide a real-world application of network health monitoring using DEVS/SOA-layered architectural framework.

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Background: Primary progressive aphasia (PPA) is a clinical syndrome characterized by the neurodegeneration of language brain systems. Three main clinical forms (non-fluent, semantic, and logopenic PPA) have been recognized, but applicability of the classification and the capacity to predict the underlying pathology is controversial. We aimed to study FDG-PET imaging data in a large consecutive case series of patients with PPA to cluster them into different subtypes according to regional brain metabolism.Methods: 122 FDG-PET imaging studies belonging to 91 PPA patients and 28 healthy controls were included. We developed a hierarchical agglomerative cluster analysis with Ward's linkage method, an unsupervised clustering algorithm. We conducted voxel-based brain mapping analysis to evaluate the patterns of hypometabolism of each identified cluster.Results: Cluster analysis confirmed the three current PPA variants, but the optimal number of clusters according to Davies-Bouldin index was 6 subtypes of PPA. This classification resulted from splitting non-fluent variant into three subtypes, while logopenic PPA was split into two subtypes. Voxel-brain mapping analysis displayed different patterns of hypometabolism for each PPA group. New subtypes also showed a different clinical course and were predictive of amyloid imaging results.Conclusion: Our study found that there are more than the three already recognized subtypes of PPA. These new subtypes were more predictive of clinical course and showed different neuroimaging patterns. Our results support the usefulness of FDG-PET in evaluating PPA, and the applicability of computational methods in the analysis of brain metabolism for improving the classification of neurodegenerative disorders.

Chronic patients must carry out a rigorous control of diverse factors in their lives. Diet, sport activity, medical analysis or blood glucose levels are some of them. This is a hard task, because some of these controls are performed very often, for instance some diabetics measure their glucose levels several times every day, or patients with chronic renal disease, a progressive loss in renal function, should strictly control their blood pressure and diet. In order to facilitate this task to both the patient and the physician, we have developed a web application for chronic diseases control which we have particularized to diabetes. This system, called glUCModel, improves the communication and interaction between patients and doctors, and eventually the quality of life of the former. Through a web application, patients can upload their personal and medical data, which are stored in a centralized database. In this way, doctors can consult this information and have a better control over patient records. glUCModel also presents three novelties in the disease management: a recommender system, an e-learning course and a module for automatic generation of glucose levels model. The recommender system uses Case Based Reasoning. It provides automatic recommendations to the patient, based on the recorded data and physician preferences, to improve their habits and knowledge about the disease. The e-learning course provides patients a space to consult information about the illness, and also to assess their own knowledge about the disease. Blood glucose levels are modeled by means of evolutionary computation, allowing to predict glucose levels using particular features of each patient. glUCModel was developed as a system where a web layer allows the access of the users from any device connected to the Internet, like desktop computers, tablets or mobile phones.

Background The analysis of health and medical data is crucial for improving the diagnosis precision, treatments and prevention. In this field, machine learning techniques play a key role. However, the amount of health data acquired from digital machines has high dimensionality and not all data acquired from digital machines are relevant for a particular disease. Primary Progressive Aphasia (PPA) is a neurodegenerative syndrome including several specific diseases, and it is a good model to implement machine learning analyses. In this work, we applied five feature selection algorithms to identify the set of relevant features from 18F-fluorodeoxyglucose positron emission tomography images of the main areas affected by PPA from patient records. On the other hand, we carried out classification and clustering algorithms before and after the feature selection process to contrast both results with those obtained in a previous work. We aimed to find the best classifier and the more relevant features from the WEKA tool to propose further a framework for automatic help on diagnosis. Dataset contains data from 150 FDG-PET imaging studies of 91 patients with a clinic prognosis of PPA, which were examined twice, and 28 controls. Our method comprises six different stages: (i) feature extraction, (ii) expertise knowledge supervision (iii) classification process, (iv) comparing classification results for feature selection, (v) clustering process after feature selection, and (vi) comparing clustering results with those obtained in a previous work. Results Experimental tests confirmed clustering results from a previous work. Although classification results for some algorithms are not decisive for reducing features precisely, Principal Components Analisys (PCA) results exhibited similar or even better performances when compared to those obtained with all features. Conclusions Although reducing the dimensionality does not means a general improvement, the set of features is almost halved and results are better or quite similar. Finally, it is interesting how these results expose a finer grain classification of patients according to the neuroanatomy of their disease.

New portable consumer embedded devices must execute multimedia applications (e.g., 3D games, video players and signal processing software, etc.) that demand extensive memory accesses and memory usage at a low energy consumption. Moreover, they must heavily rely on Dynamic Memory (DM) due to the unpredictability of the input data and system behavior. Within this context, consistent design methodologies that can tackle efficiently the complex DM behavior of these multimedia applications are in great need. In this article, we present a novel design framework, based on genetic programming, which allows us to design custom DM management mechanisms, optimizing memory accesses, memory use and energy consumption for the target embedded system. First, we describe the large design space of DM management decisions for multimedia embedded applications. Then, we propose a suitable way to traverse this design space using grammatical evolution and construct custom DM managers that minimize the DM used by these highly dynamic applications. As a result, our methodology achieves significant improvements in memory accesses (23% less on average), memory usage (38% less on average) and energy consumption (reductions of 21% on average) in real case studies over the current state-of-the-art DM managers used for these types of dynamic applications. To the best of our knowledge, this is the first approach to efficiently design DM managers for embedded systems using evolutionary computation and grammar evolution.