The effect of yeast beta-1, 3-glucan as an immunopotentiator of delayed type-hypersensitivity reactions (DHR) was studied. Delayed-type-hypersensitivity reactions in mice sensitized intraperitoneally (IP) with sheep red blood cells (SRBC) and pretreated three days previously with glucan given IP were significantly increased. However, mice sensitized IP with SRBC three days after the subcutaneous (SC) administration of glucan showed depressed DHR. Glucan given at the same site but not at distance strongly potentiated the DHR induced by SC sensitization with SRBC. Subcutaneous injection of glucan and SRBC given together also resulted in a sustained DHR which persisted twelve days after sensitization when DHR of control mice had waned.
In the present study we measured the blastogenic response of lymph node cells from BALB/c mice infected with Leishmania mexicana throughout the course of infection. Results showed that infected mice displayed normal blastogenic responses in the lymph nodes until twenty weeks of infection. Thereafter, there was a gradual suppression. Comparison of the immunoresponsiveness in the spleen and lymph nodes, revealed normal responses in the lymph nodes several weeks after suppression in the spleen had occurred. Suppression of blastogenic responses in the lymph nodes was related to an adherent macrophage-like cell which actively suppressed normal proliferative responses to mitogens.
José Bolivar inicia su artículo con la censura en Colombia del documental No hubo tiempo para la tristeza, que retrata el conflicto armado del país; parte de esta mención para hablar de la creciente violencia que está sufriendo Colombia y cómo ni la institución ni la ciudadanía se preocupan por visibilizarla. Apunta que el estado le resta importancia a los procesos de la memoria, que son tan necesarios para vivir un duelo, crear lenguajes para contar lo padecido y sanar. Insiste en lo importante que es no olvidar y difundir las acciones violentas que suceden dentro del país.
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