Key indicators: single-crystal X-ray study; T = 293 K; mean (C-C) = 0.003 Å; R factor = 0.057; wR factor = 0.183; data-to-parameter ratio = 26.2.In the title compound, C 16 H 10 N 2 S 2 , the thienyl rings are inclined to one another by 62.71 (10) , and are inclined by 63.94 (8) and 21.35 (8) to the quinoline mean plane [maximum deviation = 0.031 (2) Å ]. In the crystal, the molecules pack in a herringbone pattern, with -stacking interactions [centroid-centroid distances = 3.7381 (15)
Patients with polycythemia vera (PV) are at increased risk of thrombosis and hemorrhages. Although hydroxyurea (HU) has been the frontline therapy for patients at high-risk of vascular complications, about 25% of patients develop resistance/intolerance to this therapy. The aim of this non-interventional, multicenter cohort study was to understand the clinical characteristics and HU treatment response of Portuguese PV patients. HU resistance/intolerance was defined according to adjusted European LeukemiaNet (ELN) criteria. 134 PV patients with a mean disease duration of 4.8±5.0 years were included and followed up for 2 years. At baseline, most patients were ≥60 years old (83.2%), at high risk for thrombotic events (87.2%), and receiving HU therapy (79.1%). A total of 10 thrombotic events and 8 hemorrhagic events were reported, resulting in a 5-year probability of thrombo-hemorrhagic events of 17.2%. Hematocrit (p=0.007), hemoglobin (p=0.012) and MPN10 symptom score (12.0±11.6 vs 10.3±9.1; p=0.041) decreased significantly at the 24-month visit compared to baseline. Overall, 75.9% of patients met at least one of the adjusted ELN criteria for HU resistance. 14.4% of patients remained on HU throughout the study. The results from this real-world study may help identify the subset of patients at higher risk of disease sequelae who may benefit from earlier second-line treatment.
A primeira reabilitação do conceito de alegoria realizada pelo filósofo Walter Benjamin encontra-se em sua teoria sobre as peças do drama trágico alemão, na obra <em>Origem do Drama Trágico Alemão</em>. Buscaremos, no desenvolvimento deste artigo, apresentar uma breve introdução sobre a obra de Benjamin, cuja prioridade será a explanação da teoria benjaminiana da alegoria relacionada com a produção da arte do Barroco do século XVII. Procuraremos, ainda, discutir as peculiaridades filosóficas, históricas e teológicas dessa teoria, atentando, sobretudo, para sua constituição como expressão de uma época
A proposta deste artigo é discutir alguns aspectos da modificação da estrutura material de Paris destacados por Walter Benjamin no Projeto das Passagens. Para tal, destacaremos o poema "O cisne" (Le cygne) de Charles Baudelaire e a reurbanização promovida pelo Barão de Haussmann no século XIX.
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