3628 Background: Published literature points towards the disproportionate prevalence of colorectal cancer (CRC) in ethnic groups. Racial minorities are also prone to higher mortality due to inequalities in access to healthcare. Therefore, we examined the disparities in hospital-related outcomes among racial groups from CRC. Methods: We investigated the National Inpatient Sample 2019 employing International Classification of Diseases-10 (ICD-10) codes to include adult patients with CRC. We compared various outcomes stratified by racial groups with White as the reference group. Analyses were performed using STATA (v 14.2), considering 2 sided P< 0.05 as statistically significant. Proportions were compared using Fisher exact test and continuous variables using Student’s t-test. Confounding variables were adjusted using multivariate logistic and linear regression analyses and included: gender, Charlson Comorbidity Index, median household income for patients’ zip codes, hospital location/region/bedside, and insurance status. Results: Out of 732,492 included patients, 72.77% White, 13.66% African American (AA), 9.91% Hispanics, and 3.65% Asians were in the cohort. AA and Asians had higher mortality odds than White, while Hispanics had mortality similar to White. AA had a lower mean length of stay by 0.74 days than White. All racial groups incurred higher mean total charges compared to White. AA and Hispanics had lower odds of undergoing colectomy. Overall, all racial groups had high morbidity compared to White. Among subgroups, the odds of morbidity markers (sepsis, lower GI bleed, and acute renal failure) were higher in AA and Asians than Hispanics. Post-op adhesions and DVT/PE were not significantly different among racial groups. Conclusions: AA and Asians disproportionately suffer from higher mortality from colorectal cancer than Hispanics and White. Lower colectomy rates (a definitive CRC treatment) in AA and higher in-hospital complication burden in Asians are possible explanations; however, further research needs to establish if race-specific genomics are also responsible for disparities. [Table: see text]
e16098 Background: Hyponatremia has historically been reported to increase mortality and length of stay in hospitalized patients with solid tumors. There are sparse reports of hyponatremia linked to gastric cancer in the published literature. Therefore, we evaluated mortality, morbidity, and resource utilization in gastric cancer patients secondary to hyponatremia. Methods: We investigated the National Inpatient Sample 2019 employing International Classification of Diseases-10 (ICD-10) codes to include adult patients with gastric cancer. Effect of hyponatremia was studied on mortality, morbidity, and resource utilization. Analyses were performed using STATA (v 14.2), considering 2 sided P< 0.05 as statistically significant. Proportions were compared using Fisher exact test and continuous variables using Student’s t-test. Confounding variables were adjusted using multivariate logistic and linear regression analyses. These included: gender, race, Charlson Comorbidity Index, chronic kidney disease, congestive heart failure, cirrhosis, nephrotic syndrome, hypothyroidism, adrenal insufficiency, alcohol use disorder, and admission for hypovolemia or psychogenic polydipsia and various patient and hospital characteristics. Results: Out of 43,015 patients with gastric cancer in 2019, 13.59% (5,845) had hyponatremia on presentation (Table. 1). Patients with hyponatremia had 12.23% in-hospital mortality, while 6.69% for patients without hyponatremia. After adjusting for confounders, hyponatremia imparted higher odds of mortality (Adjusted odds ratio (aOR) for mortality 1.89, 95% confidence interval (CI): 1.54–2.32, P< 0.01). Hyponatremia also resulted in higher resource utilization marked by the length of stay, hospital charges, and ICU admission (higher mean LOS by 2.09 days, higher mean total hospital charges by $22,320, and higher odds of ICU admission). In addition, patients with hyponatremia had higher odds of acute renal failure (aOR 2.38, 95% CI: 2.05–2.77, P< 0.01). Rates of cerebral edema and altered mental status were equal between the two study groups ( P> 0.05). Conclusions: Hyponatremia in gastric cancer patients had a prevalence of 13.59% and resulted in increased in-hospital mortality. Whether time-efficient treatment of hyponatremia would help reduce mortality and improve outcomes remains to be determined in future studies.[Table: see text]
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