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that CoronaVac can act as an inciting factor that activates the same pathway of EM leading to a type III or IV of hypersensitivity either by the vaccine itself or to its components. 8 Erythema multiforme following vaccination is rare, just as other major adverse events and should not discourage the use of vaccines. Also, the rarity of the disease makes it hard to establish a causal link. But since we are just at the beginning about learning of the novel anti-SARS-CoV-2 vaccines, it is important to be aware about its possible cutaneous adverse reactions.

Acne fulminans (AF) is a severe form of inflammatory acne, characterized by an abrupt explosive flare of multiple ulceronecrotic lesions, which can be associated with systemic symptoms. 1 We report the first case of therapy-refractory AF successfully treated with apremilast, and discuss the benefits of this medication.A 15-year-old-adolescent with personal history of overweight and acne conglobata was started on isotretinoin 0.4 mg/kg/day. Six weeks later, he presented at the emergency department with a sudden worsening of his acne with numerous painful papules, pustules, and hemorrhagic nodules with crusts, widely distributed over his back and chest (Figure 1A). He associated fever, mild diffuse myalgias and