Highlights d Hippo signaling inhibition reprograms Lgr5+ ISCs to a Klf6+ wound-healing cell state d Klf6+ cells are characterized by low Wnt activity and reduced stemness d YAP activation suppresses tumor growth in human and mouse metastatic CRC d YAP/TAZ deletion increases colon tumor growth
Highlights d Lats1/2 kinases are required to sustain Wnt pathway and intestinal stem cells d Identification of a TEAD auto-palmitoylation inhibitor enables in vivo analysis d Nuclear YAP/TAZ interact with Groucho/TLE to block TCFmediated transcription d Dual inhibition of TEAD and Lats suppresses Myc in APCmutated intestine
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