Contemporaries of Charles Darwin were divided on reconciling his theory of natural selection with religion and morality. Although Alfred Russel Wallace stands out as a spiritualist advocate of natural selection who rejected a natural origin of morality, the science popularizer and spiritualist Arabella Buckley (1840–1929) offers a more representative example of how theists, whether spiritualist or more orthodox in their religion, found reconciliation. Unlike Wallace, Buckley emphasized the lawful evolution of morality and of the soul, drawing from the theological tradition of traducianism. Significantly, Buckley argued for a mutualistic and deeply theistic interpretation of Darwinian evolution, particularly the evolution of morals, without sacrificing the uniformity of natural law. Though Buckley's understanding of the evolutionary epic has been represented as emphasizing mutualism (Gates 1998) and spiritualist theology (Lightman 2007), here I demonstrate that her distinctive addition to the debate lies in her unifying theory of traducianism. In contrast to other authors, I argue that through Buckley we better understand Victorian spiritualism as more of a religion than an occult science. However, it was a conception of religion that, through her evolutionary traducianism, bridged science and spiritualism. This offers historians a more complex but satisfying image of the Victorian worldview after Darwin.
Background Acute Ischemic Stroke (AIS), a major cause of disability, was previously associated with multiple metabolomic changes, but many findings were contradictory. Case-control and longitudinal study designs could have played a role in that. To clarify metabolomic changes, we performed a simultaneous comparison of ischemic stroke metabolome in acute, chronic stages of stroke and controls. Methods Through the nuclear magnetic resonance (NMR) platform, we evaluated 271 serum metabolites from a cohort of 297 AIS patients in acute and chronic stages and 159 controls. We used Sparse Partial Least Squares-Discriminant analysis (sPLS-DA) to evaluate group disparity; multivariate regression to compare metabolome in acute, chronic stages of stroke and controls; and mixed regression to compare metabolome acute and chronic stages of stroke. We applied false discovery rate (FDR) to our calculations. Results The sPLS-DA revealed separation of the metabolome in acute, chronic stages of stroke and controls. Regression analysis identified 38 altered metabolites. Ketone bodies, branched-chain amino acids (BCAAs), energy, and inflammatory compounds were elevated in the acute stage, but declined in the chronic stage, often to the same levels as in controls. Levels of other amino acids, phosphatidylcholines, phosphoglycerides, and sphingomyelins mainly did not change between acute and chronic stages, but was different comparing to controls. Conclusion Our pilot study identified metabolites associated with acute stage of ischemic stroke and those that are altered in stroke patients comparing to controls regardless of stroke acuity. Future investigation in a larger independent cohort is needed to validate these findings.
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