In 20 subjects, we recorded the pattern-reversal visual evoked cortical potential (VECP) over a period of 30 min. We could not find any remarkable alterations of the peak times, they were unchanged over the time. During the first 10 min, the amplitudes showed a clear tendency to decrease if one evaluated the averaging value of the whole group. After this time, there were no significant changes. But we learned a quite different behavior of amplitudes evaluating the record of each subject. We found 5 types of different behavioral modulated responses. The problems of long-term investigation are sophisticated and need further investigation to learn which different factors have an impact on VECP. From a clinical point of view, a long-term investigation shows no relevant potential alterations.
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