In the field of medicinal chemistry, the precise installation of a trideuteromethyl group is gaining ever‐increasing attention. Site‐selective incorporation of the deuterated “magic methyl” group can provide profound pharmacological benefits and can be considered an important tool for drug optimization and development. This review provides a structured overview, according to trideuteromethylation reagent, of currently established methods for site‐selective trideuteromethylation of carbon atoms. In addition to CD3, the selective introduction of CD2H and CDH2 groups is also considered. For all methods, the corresponding mechanism and scope are discussed whenever reported. As such, this review can be a starting point for synthetic chemists to further advance trideuteromethylation methodologies. At the same time, this review aims to be a guide for medicinal chemists, offering them the available C−CD3 formation strategies for the preparation of new or modified drugs.

Faraday rotation (FR), a magneto-optic (MO) property of a material, is the rotation of the plane of polarization of light by a magnetic field in the direction of the propagation of the light. Being able to use this effect for measuring very small magnetic fields requires efficient Faraday-active materials, which combine high activity with low losses of light intensity. In search of such materials, we examined the FR of a room temperature discotic liquid crystal. When homeotropically aligned, a large MO response was observed, which only occurred when the magnetic field was perpendicular and the electric field was parallel to the liquid crystal director. The MO response could be further enhanced by changing the intermolecular distance by mixing in another compound to relief sterical hindrance. Combined with the excellent optical transparency in the visible part of the spectrum, we have identified a new MO material that shows great potential for use in demanding applications.

In the field of medicinal chemistry, the precise installation of a trideuteromethyl group is gaining everincreasing attention. Site-selective incorporation of the deuterated "magic methyl" group can provide profound pharmacological benefits and can be considered an important tool for drug optimization and development. This review provides a structured overview, according to trideuteromethylation reagent, of currently established methods for site-selective trideuteromethylation of carbon atoms. In addition to CD 3 , the selective introduction of CD 2 H and CDH 2 groups is also considered. For all methods, the corresponding mechanism and scope are discussed whenever reported. As such, this review can be a starting point for synthetic chemists to further advance trideuteromethylation methodologies. At the same time, this review aims to be a guide for medicinal chemists, offering them the available CÀ CD 3 formation strategies for the preparation of new or modified drugs.