Various effects of acorn extract have been reported including antioxidant activity, cytotoxicity against cancer cells, and the levels of acetylcholine and its related enzyme activities in the dementia mouse models. However, it is unclear whether acorn extract inhibits glutamate-induced calcium signaling in hippocampal neurons. This study was an investigation into the effect of acorn extract on intracellular free Ca ] i ) can also be elevated by the release of Ca 2+ from IP 3 -sensitive intracellular stores through the metabotrophic glutamate receptor-induced activation of phospholipase C (PLC). Ca 2+ plays a role as an intracellular messenger and a key regulatory factor for a large number of cellular processes such as muscle contraction, metabolism, secretion or even cell differentiation and apoptosis.
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