Since the inception of rituximab in the 1990s, anti-CD20 monoclonal antibodies have revolutionised the treatment of B cell hematological malignancies and have become a cornerstone of modern gold-standard practice. Additionally, the potent efficacy of these agents in depleting the B cell compartment has been used in the management of a broad array of autoimmune diseases. Multiple iterations of these agents have been investigated and are routinely used in clinical practice. In this review, we will discuss the physiology of CD20 and its attractiveness as a therapeutic target, as well as the pharmacology, pre-clinical and clinical data for the major anti-CD20 monoclonal antibodies: rituximab, obinutuzumab and ofatumumab.

We examine the demand for audited financial statements in the context of deregulation. In 1994 a change in Canadian legislation eliminated a mandatory requirement for certain private companies to file audited financial statements. The objective of this research was to determine the importance of factors that might influence whether the audit is discontinued. Information was obtained from the Cancorp Plus database and through a survey of companies affected by the change in legislation. It was found that a large majority of the companies retained their audit. The strongest predictors of whether the audit would be retained were the prior existence of a lending agreement requiring audited financial statements and the level of audit fees. The likelihood of retention was positively related to the magnitude of fees, perhaps reflecting the perceived benefits of the audit. The existence of a lending agreement was found to be influenced by the ownership level of the entity's officers and directors. This study underlines the importance of audited financial statements to lenders.

Purpose: Management of eosinophilic esophagitis (EoE) varies from center to center. In this study, we evaluated the effectiveness of a dairy-free diet (DFD) and the 6-Food Elimination Diet (SFED) as initial therapies for the treatment of EoE in our practice. Methods: This was a retrospective study of children who had been treated for EoE at

Key Points Practices in early-stage FL are variable and include radiation alone, systemic therapy, CMT, or observation. Each practice resulted in similar excellent outcomes; randomized trials are required to determine the optimal treatment.

The primary aim of the present article was to review the effect and the clinical significance of abutment dis-and reconnection on the peri-implant marginal bone levels.Materials and methods: English articles published from 2009 to April 2019 were identified on the MED-LINE, Cochrane Library, and PubMed databases, according to the PRISMA guidelines. Comparative in vivo studies on humans were included.Results: A total of 4 studies with different levels of bias were included in this review. A significant heterogeneity of the reported data was observed, which limited the compar-ison of the findings. The only parameter that was homogenous throughout all 4 studies was the marginal bone level measurement.Conclusion: Within the limitations of the present review, it can be suggested that minimizing the number of abutment dis-and reconnections would be beneficial to ensure minimal disruption to the peri-implant tissue and marginal bone level. However, the clinical significance of the marginal bone level changes is still inconclusive.