790. Urinary outputs of oxalate, calcium, and magnesium in children with intestinal disorders: potential cause of renal calculi. 24-hour urinary outputs of oxalate, calcium, and magnesium have been determined in a total of 62 children aged 3 months to 17 years who fell into the following groups: (i) 16 normal controls, (ii) 3 with primary hyperoxaluria, (iii) 9 with small and/or large intestinal resections, (iv) 9 with untreated coeliac disease, (v) 5 with pancreatic dysfunction, and (vi) a miscellaneous group of 20 children with a variety of intestinal disorders.Taken as a whole, 58% of patients with intestinal disorders had hyperoxaluria, and of these 7 % had urinary outputs of oxalate which fell within the range seen in primary hyperoxaluria. The proportion of children with hyperoxaluria in the different diagnostic groups was as follows: intestinal resections (78%), coeliac disease (67%), pancreatic dysfunction (80%), and miscellaneous (45%). 35% of the patients with hyperoxaluria had hypercalciuria, whereas magnesium excretion was normal in all subjects studied. In 2 patients treatment of the underlying condition was accompanied by a return of oxalate excretion to normal.These results indicate that hyperoxaluria and hypercalciuria are common in children with a variety of intestinal disorders, and that such children may be at risk of developing renal calculi without early diagnosis and treatment.Hyperoxaluria is common in adult patients with ileal disease or resection, and a proportion of these patients develop oxalate renal calculi (Dowling, Rose, and Sutor, 1971; Smith, Fromm, and Hofmann, 1972;Chadwick, Modha, and Dowling, 1973
