With its roots in kinetic theory and the cellular automaton concept, the lattice-Boltzmann (LB) equation can be used to obtain continuum flow quantities from simple and local update rules based on particle interactions. The simplicity of formulation and its versatility explain the rapid expansion of the LB method to applications in complex and multiscale flows. We review many significant developments over the past decade with specific examples. Some of the most active developments include the entropic LB method and the application of the LB method to turbulent flow, multiphase flow, and deformable particle and fiber suspensions. Hybrid methods based on the combination of the Eulerian lattice with a Lagrangian grid system for the simulation of moving deformable boundaries show promise for more efficient applications to a broader class of problems. We also discuss higher-order boundary conditions and the simulation of microchannel flow with finite Knudsen number. Additionally, the remarkable scalability of the LB method for parallel processing is shown with examples. Teraflop simulations with the LB method are routine, and there is no doubt that this method will be one of the first candidates for petaflop computational fluid dynamics in the near future.

A novel method is developed to simulate suspensions of deformable particles by coupling the lattice-Boltzmann method (LBM) for the fluid phase to a linear finiteelement analysis (FEA) describing particle deformation. The methodology addresses the need for an efficient method to simulate large numbers of three-dimensional and deformable particles at high volume fraction in order to capture suspension rheology, microstructure, and self-diffusion in a variety of applications. The robustness and accuracy of the LBM-FEA method is demonstrated by simulating an inflating thinwalled sphere, a deformable spherical capsule in shear flow, a settling sphere in a confined channel, two approaching spheres, spheres in shear flow, and red blood cell deformation in flow chambers. Additionally, simulations of suspensions of hundreds of biconcave red blood cells at 40 % volume fraction produce continuum-scale physics and accurately predict suspension viscosity and the shear-thinning behaviour of blood. Simulations of fluid-filled spherical capsules which have red-blood-cell membrane properties also display deformation-induced shear-thinning behaviour at 40 % volume fraction, although the suspension viscosity is significantly lower than blood.

SUMMARYThe implementation of a spectrin-link (SL) red blood cell (RBC) membrane method coupled with a lattice-Boltzmann (LB) fluid solver is discussed. Details of the methodology are included along with subtleties associated with its integration into a massively parallel hybrid LB finite element (FE) suspension flow solver. A comparison of the computational performance of the coupled LB-SL method with that of the previously implemented LB-FE is given for an isolated RBC and for a dense suspension in HagenPoiseuille flow. Validating results for RBCs isolated in shear and parachuting in microvessel flow are also presented.

A detailed study into the rheology and microstructure of dense suspensions of initially spherical capsules is presented, where capsules are composed of a fluid-filled interior surrounded by an elastic membrane. This study couples a lattice-Boltzmann fluid solver to a finite-element membrane model creating a robust and scalable method for the simulation of these suspensions. A Lees–Edwards boundary condition is used to simulate periodic simple shear to obtain bulk rheological properties, and three-dimensional results are presented for capsules in the regime of negligible inertia, Brownian motion and colloidal interparticle forces. The simulation results focus on describing the suspension rheology as a function of the particle concentration and deformability, and relating these macroscopic rheological findings to changes at the particle level, i.e. the suspension microstructure. Several important findings are made: suspensions of deformable capsules are found to be shear thinning, and the initially compressive normal stresses associated with rigid spherical suspensions undergo rapid changes with moderate levels of particle deformation. These normal stress changes are particularly evident in the first normal stress difference, which undergoes a sign change at fairly minor levels of deformation, and the particle pressure, which decreases rapidly with increasing particle deformability. Changes in the microstructure as quantified by the single-body microstructure and the pair distribution function are reported. Also, results calculating particle self-diffusion are presented and related to changes in the normal stresses.

The biotransport of the intravascular nanoparticle (NP) is influenced by both the complex cellular flow environment and the NP characteristics. Being able to computationally simulate such intricate transport phenomenon with high efficiency is of far-reaching significance to the development of nanotherapeutics, yet challenging due to large length-scale discrepancies between NP and red blood cell (RBC) as well as the complexity of NP dynamics. Recently, a lattice-Boltzmann (LB) based multiscale simulation method has been developed to capture both NP scale and cellular level transport phenomenon at high computational efficiency. The basic components of this method include the LB treatment for the fluid phase, a spectrin-link method for RBCs, and a Langevin dynamics (LD) approach to capturing the motion of the suspended NPs. Comprehensive two-way coupling schemes are established to capture accurate interactions between each component.The accuracy and robustness of the LB-LD coupling method are demonstrated through the relaxation of a single NP with initial momentum and self-diffusion of NPs. This approach is then applied to study the migration of NPs in a micro-vessel under physiological conditions. It is shown that Brownian motion is most significant for the NP distribution in 20 vessels. For 1~100 particles, the Brownian diffusion is the dominant radial diffusive 2 mechanism compared to the RBC-enhanced diffusion. For ~500 particles, the Brownian diffusion and RBC-enhanced diffusion are comparable drivers for the particle radial diffusion process.