The purpose of this study was to determine the pharmacokinetics of phenytoin, theophylline, and diazepam in six healthy Greyhound dogs. Additionally the pharmacokinetics of the diazepam metabolites oxazepam and nordiazepam after diazepam administration were determined. Phenytoin sodium (12 mg/kg), aminophylline (10 mg/kg), and diazepam (0.5 mg/kg) were administered IV on separate occasions and blood obtained at predetermined time points for the quantification of plasma drug concentrations by florescence polarization immunoassay (phenytoin, theophylline) or mass spectrometry (diazepam, oxazepam, nordiazepam). The terminal half-life was 4.9, 9.2, and 1.0 hours, respectively for phenytoin, theophylline, and diazepam, and 6.2 and 2.4 hours for oxazepam and nordiazepam after IV diazepam. The clearance was of 2.37, 0.935, and 27.9 mL/min/kg respectively for phenytoin, theophylline, and diazepam. The CMAX was 44.7 and 305.2 ng/mL for oxazepam and nordiazepam, respectively, after diazepam administration. Temazepam was not detected above 5 ng/mL in any sample after IV diazepam.
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